Localization of the human prealbumin gene to chromosome 18

Margaret R. Wallace, Susan L. Naylor, Barbara Kluve-Beckerman, George L. Long, Lisa McDonald, Thomas B. Shows, Merrill D. Benson

Research output: Contribution to journalArticle

88 Scopus citations

Abstract

A human liver cDNA library was screened using an oligonucleotide probe based on the amino acid sequence of human prealbumin. The cDNA insert of one positive clone was sequenced and found to contain the entire coding sequence of human prealbumin plus untranslated 5′ and 3′ regions. This cDNA was used to probe DNA from a panel of mouse/human somatic cell hybrids. Only those hybrids containing human chromosome 18 showed the human-specific hybridization pattern, thereby localizing the human prealbumin gene to this chromosome.

Original languageEnglish (US)
Pages (from-to)753-758
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume129
Issue number3
DOIs
StatePublished - Jun 28 1985

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ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Wallace, M. R., Naylor, S. L., Kluve-Beckerman, B., Long, G. L., McDonald, L., Shows, T. B., & Benson, M. D. (1985). Localization of the human prealbumin gene to chromosome 18. Biochemical and Biophysical Research Communications, 129(3), 753-758. https://doi.org/10.1016/0006-291X(85)91956-4