Locomotor Sensitization to Cocaine in Rats with Olfactory Bulbectomy

R. Andrew Chambers, Teige Sheehan, Jane R. Taylor

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Olfactory bulbectomy in rats has been suggested as a comprehensive animal model of affective disorders associated with an array of behavioral changes, responsivity to chronic antidepressant treatment, and alterations in limbic structures thought to be critical in the pathophysiology of affective disorders. Recent work showing increased motivational responsivity to amphetamine suggests that olfactory bulbectomy could also be a useful animal model of dual diagnosis disorders. To further investigate this possibility, we studied locomotor activity in olfactory bulbectomized rats 14 days postsurgery in response to novelty and upon acute and repeated injections of cocaine (15/mg/kg) or saline. Consistent with prior studies, lesioned animals showed greater locomotor activity in response to a novel environment and significantly heightened locomotor activation upon initial cocaine exposure. Over 7 days of repeated cocaine injections, lesioned animals also showed a presensitized pattern of activity, with a loss of incremental increases in locomotion observed in control animals. Daily saline injections produced no group differences in pre- or postinjection activity, while cocaine-treated bulbectomized rats demonstrated a decline in their daily preinjection activity. These results suggest that neural alterations caused by olfactory bulbectomy produce altered behavioral response patterns to repeated doses of cocaine, and support the study of olfactory bulbectomy as a useful neurobehavioral model for understanding substance use disorder comorbidity in mental illness.

Original languageEnglish (US)
Pages (from-to)167-175
Number of pages9
JournalSynapse
Volume52
Issue number3
DOIs
StatePublished - Jun 1 2004

Fingerprint

Cocaine
Locomotion
Mood Disorders
Injections
Animal Models
Dual (Psychiatry) Diagnosis
Amphetamine
Antidepressive Agents
Substance-Related Disorders
Comorbidity
Therapeutics

Keywords

  • Addiction
  • Affective disorders
  • Cocaine
  • Dual diagnosis
  • Substance use disorders

ASJC Scopus subject areas

  • Neuroscience(all)
  • Physiology
  • Pharmacology

Cite this

Locomotor Sensitization to Cocaine in Rats with Olfactory Bulbectomy. / Chambers, R. Andrew; Sheehan, Teige; Taylor, Jane R.

In: Synapse, Vol. 52, No. 3, 01.06.2004, p. 167-175.

Research output: Contribution to journalArticle

Chambers, R. Andrew ; Sheehan, Teige ; Taylor, Jane R. / Locomotor Sensitization to Cocaine in Rats with Olfactory Bulbectomy. In: Synapse. 2004 ; Vol. 52, No. 3. pp. 167-175.
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