Long non-coding RNA and chromatin remodeling

Pei Han, Ching-Pin Chang

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Long noncoding RNAs (lncRNAs) are pivotal regulators of genome structure and gene expression. LncRNAs can directly interact with chromatin-modifying enzymes and nucleosome-remodeling factors to control chromatin structure and accessibility of genetic information. Moreover, lncRNA expression can be controlled by chromatin-remodeling factors, suggesting a feedback circuit of regulation. Here, we discuss the recent advances of lncRNA studies, focusing on the function and mechanism of lncRNA– chromatin interactions.

Original languageEnglish (US)
Pages (from-to)1094-1098
Number of pages5
JournalRNA Biology
Volume12
Issue number10
DOIs
StatePublished - 2015

Fingerprint

Long Noncoding RNA
Chromatin Assembly and Disassembly
Chromatin
Nucleosomes
Genetic Structures
Genome
Gene Expression
Enzymes

Keywords

  • Chromatin modification
  • Chromatin remodeling
  • Human diseases
  • lncRNA promoter
  • lncRNA regulation
  • Long non-coding RNA
  • RNA therapeutics

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

Cite this

Long non-coding RNA and chromatin remodeling. / Han, Pei; Chang, Ching-Pin.

In: RNA Biology, Vol. 12, No. 10, 2015, p. 1094-1098.

Research output: Contribution to journalArticle

Han, Pei ; Chang, Ching-Pin. / Long non-coding RNA and chromatin remodeling. In: RNA Biology. 2015 ; Vol. 12, No. 10. pp. 1094-1098.
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