Long non-coding RNA and chromatin remodeling

Pei Han, Ching Pin Chang

Research output: Contribution to journalArticle

71 Scopus citations

Abstract

Long noncoding RNAs (lncRNAs) are pivotal regulators of genome structure and gene expression. LncRNAs can directly interact with chromatin-modifying enzymes and nucleosome-remodeling factors to control chromatin structure and accessibility of genetic information. Moreover, lncRNA expression can be controlled by chromatin-remodeling factors, suggesting a feedback circuit of regulation. Here, we discuss the recent advances of lncRNA studies, focusing on the function and mechanism of lncRNA– chromatin interactions.

Original languageEnglish (US)
Pages (from-to)1094-1098
Number of pages5
JournalRNA Biology
Volume12
Issue number10
DOIs
StatePublished - Jan 1 2015

Keywords

  • Chromatin modification
  • Chromatin remodeling
  • Human diseases
  • Long non-coding RNA
  • RNA therapeutics
  • lncRNA promoter
  • lncRNA regulation

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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