Long non-coding RNA in liver metabolism and disease: Current status

Yulan Zhao, Jianguo Wu, Suthat Liangpunsakul, Li Wang

Research output: Contribution to journalReview article

6 Citations (Scopus)

Abstract

Long non-coding RNAs (lncRNAs) are comprised of RNA transcripts exceeding 200 nucleotides in length but lacking identifiable open reading frames (with rare exceptions). Herein, we highlight emerging evidence demonstrating that lncRNAs are critical regulators of liver metabolic function and diseases. We summarize current knowledges about dysregulated lncRNAs and outline the underlying molecular mechanisms by which lncRNAs control hepatic lipid ad glucose metabolism, as well as cholestatic liver disease. Liver-specific triglyceride regulator (lncLSTR), Lnc18q22.2, steroid RNA activator (SRA), highly upregulated in liver cancer (HULC), metastasis associated in lung adenocarcinoma transcript 1 (MALAT1), liver glucokinase repressor (lncLGR), maternally expressed gene 3 (MEG3), and H19, lncHR1, lnc-HC, apolipoprotein A1 antisense transcript (APOA1-AS), DYNLRB2-2, and LXR-induced sequence (LeXis) are included in the discussion.

Original languageEnglish (US)
Pages (from-to)163-167
Number of pages5
JournalLiver Research
Volume1
Issue number3
DOIs
StatePublished - Sep 2017

Fingerprint

Long Noncoding RNA
Liver Diseases
Liver
RNA
Glucokinase
Apolipoprotein A-I
Metabolic Diseases
Liver Neoplasms
Open Reading Frames
Triglycerides
Nucleotides
Steroids
Neoplasm Metastasis
Lipids
Glucose
Genes

Keywords

  • Cholestatic liver disease
  • Glucose metabolism
  • Lipid metabolism
  • Liver
  • Long non-coding RNA (lncRNA)

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology

Cite this

Long non-coding RNA in liver metabolism and disease : Current status. / Zhao, Yulan; Wu, Jianguo; Liangpunsakul, Suthat; Wang, Li.

In: Liver Research, Vol. 1, No. 3, 09.2017, p. 163-167.

Research output: Contribution to journalReview article

Zhao, Yulan ; Wu, Jianguo ; Liangpunsakul, Suthat ; Wang, Li. / Long non-coding RNA in liver metabolism and disease : Current status. In: Liver Research. 2017 ; Vol. 1, No. 3. pp. 163-167.
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AB - Long non-coding RNAs (lncRNAs) are comprised of RNA transcripts exceeding 200 nucleotides in length but lacking identifiable open reading frames (with rare exceptions). Herein, we highlight emerging evidence demonstrating that lncRNAs are critical regulators of liver metabolic function and diseases. We summarize current knowledges about dysregulated lncRNAs and outline the underlying molecular mechanisms by which lncRNAs control hepatic lipid ad glucose metabolism, as well as cholestatic liver disease. Liver-specific triglyceride regulator (lncLSTR), Lnc18q22.2, steroid RNA activator (SRA), highly upregulated in liver cancer (HULC), metastasis associated in lung adenocarcinoma transcript 1 (MALAT1), liver glucokinase repressor (lncLGR), maternally expressed gene 3 (MEG3), and H19, lncHR1, lnc-HC, apolipoprotein A1 antisense transcript (APOA1-AS), DYNLRB2-2, and LXR-induced sequence (LeXis) are included in the discussion.

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