Long non-coding rnas in liver diseases: Focusing on nonalcoholic fatty liver disease, alcohol-related liver disease, and cholestatic liver disease

Sen Han, Ting Zhang, Praveen Kusumanchi, Nazmul Huda, Yanchao Jiang, Zhihong Yang, Suthat Liangpunsakul

Research output: Contribution to journalReview articlepeer-review

Abstract

Long non-coding RNAs (lncRNAs), a class of transcribed RNA molecules with the lengths exceeding 200 nucleotides, are not translated into protein. They can modulate protein-coding genes by controlling transcriptional and post-transcriptional processes. The dysregulation of lncRNAs has been related to various pathological disorders. In this review, we summarized the current knowledge of lncRNAs and their implications in the pathogenesis of three common liver diseases: nonalcoholic fatty liver disease, alcohol-related liver disease, and cholestatic liver disease. Future studies to further define the role of lncRNAs and their mechanisms in various types of liver diseases should be explored. An improved understanding from these studies will provide us a useful perspective leading to mechanism-based intervention by targeting specific lncRNAs for the treatment of liver diseases.

Original languageEnglish (US)
Pages (from-to)705-714
Number of pages10
JournalClinical and molecular hepatology
Volume26
Issue number4
DOIs
StatePublished - Oct 2020

Keywords

  • Etiology
  • Liver diseases
  • RNA, Long noncoding

ASJC Scopus subject areas

  • Hepatology
  • Molecular Biology

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