Long non-coding RNAs in renal cell carcinoma: A systematic review and clinical implications

Ming Li, Ying Wang, Liang Cheng, Wanting Niu, Guoan Zhao, Jithin K. Raju, Jun Huo, Bin Wu, Bo Yin, Yongsheng Song, Renge Bu

Research output: Contribution to journalReview article

22 Scopus citations

Abstract

Renal cell carcinoma is one of the most common malignancy in adults, its prognosis is poor in an advanced stage and early detection is difficult due to the lack of molecular biomarkers. The identification of novel biomarkers for RCC is an urgent and meaningful project. Long non-coding RNA (lncRNA) is transcribed from genomic regions with a minimum length of 200 bases and limited protein-coding potential. Recently, lncRNAs have been greatly studied in a variety of cancer types. They participate in a wide variety of biological processes including cancer biology. In this review, we provide a new insight of the profiling of lncRNAs in RCC and their roles in renal carcinogenesis, with an emphasize on their potential in diagnosis, prognosis and potential roles in RCC therapy.

Original languageEnglish (US)
Pages (from-to)48424-48435
Number of pages12
JournalOncotarget
Volume8
Issue number29
DOIs
StatePublished - 2017

Keywords

  • Diagnosis
  • LncRNA
  • Prognosis
  • Renal cell carcinoma
  • Therapy

ASJC Scopus subject areas

  • Oncology

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    Li, M., Wang, Y., Cheng, L., Niu, W., Zhao, G., Raju, J. K., Huo, J., Wu, B., Yin, B., Song, Y., & Bu, R. (2017). Long non-coding RNAs in renal cell carcinoma: A systematic review and clinical implications. Oncotarget, 8(29), 48424-48435. https://doi.org/10.18632/oncotarget.17053