Long noncoding RNAs in cardiac development and ageing

Yvan Devaux, Jennifer Zangrando, Blanche Schroen, Esther E. Creemers, Thierry Pedrazzini, Ching-Pin Chang, Gerald W. Dorn, Thomas Thum, Stephane Heymans

Research output: Contribution to journalArticle

135 Citations (Scopus)

Abstract

A large part of the mammalian genome is transcribed into noncoding RNAs. Long noncoding RNAs (lncRNAs) have emerged as critical epigenetic regulators of gene expression. Distinct molecular mechanisms allow lncRNAs either to activate or to repress gene expression, thereby participating in the regulation of cellular and tissue function. LncRNAs, therefore, have important roles in healthy and diseased hearts, and might be targets for therapeutic intervention. In this Review, we summarize the current knowledge of the roles of lncRNAs in cardiac development and ageing. After describing the definition and classification of lncRNAs, we present an overview of the mechanisms by which lncRNAs regulate gene expression. We discuss the multiple roles of lncRNAs in the heart, and focus on the regulation of embryonic stem cell differentiation, cardiac cell fate and development, and cardiac ageing. We emphasize the importance of chromatin remodelling in this regulation. Finally, we discuss the therapeutic and biomarker potential of lncRNAs.

Original languageEnglish (US)
Pages (from-to)415-425
Number of pages11
JournalNature Reviews Cardiology
Volume12
Issue number7
DOIs
StatePublished - Jul 22 2015

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Long Noncoding RNA
Gene Expression
Untranslated RNA
Chromatin Assembly and Disassembly
Regulator Genes
Embryonic Stem Cells
Epigenomics
Cell Differentiation
Heart Diseases
Biomarkers
Genome
Therapeutics

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Devaux, Y., Zangrando, J., Schroen, B., Creemers, E. E., Pedrazzini, T., Chang, C-P., ... Heymans, S. (2015). Long noncoding RNAs in cardiac development and ageing. Nature Reviews Cardiology, 12(7), 415-425. https://doi.org/10.1038/nrcardio.2015.55

Long noncoding RNAs in cardiac development and ageing. / Devaux, Yvan; Zangrando, Jennifer; Schroen, Blanche; Creemers, Esther E.; Pedrazzini, Thierry; Chang, Ching-Pin; Dorn, Gerald W.; Thum, Thomas; Heymans, Stephane.

In: Nature Reviews Cardiology, Vol. 12, No. 7, 22.07.2015, p. 415-425.

Research output: Contribution to journalArticle

Devaux, Y, Zangrando, J, Schroen, B, Creemers, EE, Pedrazzini, T, Chang, C-P, Dorn, GW, Thum, T & Heymans, S 2015, 'Long noncoding RNAs in cardiac development and ageing', Nature Reviews Cardiology, vol. 12, no. 7, pp. 415-425. https://doi.org/10.1038/nrcardio.2015.55
Devaux Y, Zangrando J, Schroen B, Creemers EE, Pedrazzini T, Chang C-P et al. Long noncoding RNAs in cardiac development and ageing. Nature Reviews Cardiology. 2015 Jul 22;12(7):415-425. https://doi.org/10.1038/nrcardio.2015.55
Devaux, Yvan ; Zangrando, Jennifer ; Schroen, Blanche ; Creemers, Esther E. ; Pedrazzini, Thierry ; Chang, Ching-Pin ; Dorn, Gerald W. ; Thum, Thomas ; Heymans, Stephane. / Long noncoding RNAs in cardiac development and ageing. In: Nature Reviews Cardiology. 2015 ; Vol. 12, No. 7. pp. 415-425.
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