Long term effect of cis diamminedichloride platinum (CDDP) on renal function and structure in man

M. Dentino, F. C. Luft, M. N. Yum, S. D. Williams, Lawrence Einhorn

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Abstract

To examine CDDP induced nephrotoxicity in patients with testicular carcinoma, the authors measured renal function prior to therapy and at six month intervals for twelve months in 15 patients and 24 months in 7 patients. CDDP was given iv at 20 mg/M 2 per day for 5 days at 3 week intervals. 8 Patients received 3 courses, 4 received 4 courses and 3 received more than 4 courses. The mean creatinine clearance ± SD prior to treatment was 112 ± 12 ml/min. By six months, it had decreased to 68.5 ± ml/min (p <0.01) and it remained at that level. Plasma creatinine and blood urea nitrogen increased significantly. Subjects receiving other potential nephrotoxins in addition to CDDP developed a greater decrease in creatinine clearance (p <0.05). Proteinuria and functional tubular disturbances were not observed. Microscopic features were characterized by hydropic degeneration of the renal tubular epithelium, thickened tubular basement membranes and mild interstitial fibrosis. Electron microscopy revealed phagolysosomes filled with flocculent material. CDDP resulted in a permanent, nonspecific renal injury in the authors' patients. Although the renal injury has remained subclinical, future courses of CDDP may lead to clinically important chronic renal failure.

Original languageEnglish (US)
Pages (from-to)1274-1281
Number of pages8
JournalCancer
Volume41
Issue number4
StatePublished - 1978

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Cisplatin
Kidney
Creatinine
Phagosomes
Blood Urea Nitrogen
Wounds and Injuries
Proteinuria
Basement Membrane
Chronic Kidney Failure
Edema
Electron Microscopy
Fibrosis
Epithelium
Carcinoma
Therapeutics

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Dentino, M., Luft, F. C., Yum, M. N., Williams, S. D., & Einhorn, L. (1978). Long term effect of cis diamminedichloride platinum (CDDP) on renal function and structure in man. Cancer, 41(4), 1274-1281.

Long term effect of cis diamminedichloride platinum (CDDP) on renal function and structure in man. / Dentino, M.; Luft, F. C.; Yum, M. N.; Williams, S. D.; Einhorn, Lawrence.

In: Cancer, Vol. 41, No. 4, 1978, p. 1274-1281.

Research output: Contribution to journalArticle

Dentino, M, Luft, FC, Yum, MN, Williams, SD & Einhorn, L 1978, 'Long term effect of cis diamminedichloride platinum (CDDP) on renal function and structure in man', Cancer, vol. 41, no. 4, pp. 1274-1281.
Dentino, M. ; Luft, F. C. ; Yum, M. N. ; Williams, S. D. ; Einhorn, Lawrence. / Long term effect of cis diamminedichloride platinum (CDDP) on renal function and structure in man. In: Cancer. 1978 ; Vol. 41, No. 4. pp. 1274-1281.
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