Long-term follow-up of composite bladder augmentation incorporating stomach in a multi-institutional cohort of patients with cloacal exstrophy

J. T. Casey, Katherine Chan, Y. Hasegawa, T. Large, B. Judge, Martin Kaefer, R. Misseri, R. C. Rink, K. Ueoka, M. P. Cain

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Introduction: Composite bladder augmentation, incorporating gastric and bowel segments, has the theoretical advantage of metabolic neutrality while potentially avoiding the morbidities of gastrocystoplasty, such as hematuria-dysuria syndrome. The most common indication for this operation is a paucity of bowel, such as in cloacal exstrophy. Despite several early descriptive studies of this technique, there are no reports, to date, of long-term follow-up in this population. Objective: To describe the outcomes of composite bladder augmentation utilizing stomach in a cohort of cloacal exstrophy patients. Materials and Methods: A retrospective review of cloacal exstrophy patients who underwent composite bladder augmentation from 1984 to 2006 at two institutions was performed. The incidence of mortality and morbidities related to augmentation was evaluated. Results: Eleven patients with cloacal exstrophy underwent composite bladder augmentation. Median age at initial augmentation was 6.4 years (interquartile range (IQR) 4.4-9.1). Median follow-up was 13.2 years (IQR 11.2-24.6). The Summary table describes the types of composite bladder augmentations. Of the three patients with pre-operative metabolic acidosis, two improved with composite bladder augmentation and one developed metabolic alkalosis. Three developed hematuria-dysuria syndrome: one improved with staged ileocystoplasty, and two had persistent symptoms successfully treated with H2 receptor blockers. Two of 11 developed symptomatic bladder stones. There were no reported bladder perforations, bladder malignancies, conversions to incontinent urinary diversions, or deaths. Conclusion: With long-term follow-up, very few patients developed metabolic acidosis/alkalosis after composite bladder augmentation. The composite bladder augmentation will continue to be used in patients with cloacal exstrophy, in order to minimize the impact on the pre-existing short gut in these patients.Summary tableDescription of the types of composite bladder augmentations.Type of composite bladder augmentationNumber of patients (%)Gastrocystoplasty onto hindgut incorporated during initial bladder closure2 (18.2%)Gastrocystoplasty with subsequent ileocystoplasty2 (18.2%)Initial composite bladder augmentation with both stomach and ileum5 (45.5%)Multiple augmentations with a final composition of stomach and ileum2 (18.2%) . .

Original languageEnglish (US)
JournalJournal of Pediatric Urology
DOIs
StateAccepted/In press - Jun 15 2016

Fingerprint

Stomach
Urinary Bladder
Dysuria
Alkalosis
Hematuria
Acidosis
Urinary Bladder Calculi
Morbidity
Histamine H2 Receptors
Urinary Diversion

Keywords

  • Bladder augmentation
  • Cloacal exstrophy
  • Gastrocystoplasty
  • Ileocystoplasty

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Urology

Cite this

Long-term follow-up of composite bladder augmentation incorporating stomach in a multi-institutional cohort of patients with cloacal exstrophy. / Casey, J. T.; Chan, Katherine; Hasegawa, Y.; Large, T.; Judge, B.; Kaefer, Martin; Misseri, R.; Rink, R. C.; Ueoka, K.; Cain, M. P.

In: Journal of Pediatric Urology, 15.06.2016.

Research output: Contribution to journalArticle

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abstract = "Introduction: Composite bladder augmentation, incorporating gastric and bowel segments, has the theoretical advantage of metabolic neutrality while potentially avoiding the morbidities of gastrocystoplasty, such as hematuria-dysuria syndrome. The most common indication for this operation is a paucity of bowel, such as in cloacal exstrophy. Despite several early descriptive studies of this technique, there are no reports, to date, of long-term follow-up in this population. Objective: To describe the outcomes of composite bladder augmentation utilizing stomach in a cohort of cloacal exstrophy patients. Materials and Methods: A retrospective review of cloacal exstrophy patients who underwent composite bladder augmentation from 1984 to 2006 at two institutions was performed. The incidence of mortality and morbidities related to augmentation was evaluated. Results: Eleven patients with cloacal exstrophy underwent composite bladder augmentation. Median age at initial augmentation was 6.4 years (interquartile range (IQR) 4.4-9.1). Median follow-up was 13.2 years (IQR 11.2-24.6). The Summary table describes the types of composite bladder augmentations. Of the three patients with pre-operative metabolic acidosis, two improved with composite bladder augmentation and one developed metabolic alkalosis. Three developed hematuria-dysuria syndrome: one improved with staged ileocystoplasty, and two had persistent symptoms successfully treated with H2 receptor blockers. Two of 11 developed symptomatic bladder stones. There were no reported bladder perforations, bladder malignancies, conversions to incontinent urinary diversions, or deaths. Conclusion: With long-term follow-up, very few patients developed metabolic acidosis/alkalosis after composite bladder augmentation. The composite bladder augmentation will continue to be used in patients with cloacal exstrophy, in order to minimize the impact on the pre-existing short gut in these patients.Summary tableDescription of the types of composite bladder augmentations.Type of composite bladder augmentationNumber of patients ({\%})Gastrocystoplasty onto hindgut incorporated during initial bladder closure2 (18.2{\%})Gastrocystoplasty with subsequent ileocystoplasty2 (18.2{\%})Initial composite bladder augmentation with both stomach and ileum5 (45.5{\%})Multiple augmentations with a final composition of stomach and ileum2 (18.2{\%}) . .",
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AU - Casey, J. T.

AU - Chan, Katherine

AU - Hasegawa, Y.

AU - Large, T.

AU - Judge, B.

AU - Kaefer, Martin

AU - Misseri, R.

AU - Rink, R. C.

AU - Ueoka, K.

AU - Cain, M. P.

PY - 2016/6/15

Y1 - 2016/6/15

N2 - Introduction: Composite bladder augmentation, incorporating gastric and bowel segments, has the theoretical advantage of metabolic neutrality while potentially avoiding the morbidities of gastrocystoplasty, such as hematuria-dysuria syndrome. The most common indication for this operation is a paucity of bowel, such as in cloacal exstrophy. Despite several early descriptive studies of this technique, there are no reports, to date, of long-term follow-up in this population. Objective: To describe the outcomes of composite bladder augmentation utilizing stomach in a cohort of cloacal exstrophy patients. Materials and Methods: A retrospective review of cloacal exstrophy patients who underwent composite bladder augmentation from 1984 to 2006 at two institutions was performed. The incidence of mortality and morbidities related to augmentation was evaluated. Results: Eleven patients with cloacal exstrophy underwent composite bladder augmentation. Median age at initial augmentation was 6.4 years (interquartile range (IQR) 4.4-9.1). Median follow-up was 13.2 years (IQR 11.2-24.6). The Summary table describes the types of composite bladder augmentations. Of the three patients with pre-operative metabolic acidosis, two improved with composite bladder augmentation and one developed metabolic alkalosis. Three developed hematuria-dysuria syndrome: one improved with staged ileocystoplasty, and two had persistent symptoms successfully treated with H2 receptor blockers. Two of 11 developed symptomatic bladder stones. There were no reported bladder perforations, bladder malignancies, conversions to incontinent urinary diversions, or deaths. Conclusion: With long-term follow-up, very few patients developed metabolic acidosis/alkalosis after composite bladder augmentation. The composite bladder augmentation will continue to be used in patients with cloacal exstrophy, in order to minimize the impact on the pre-existing short gut in these patients.Summary tableDescription of the types of composite bladder augmentations.Type of composite bladder augmentationNumber of patients (%)Gastrocystoplasty onto hindgut incorporated during initial bladder closure2 (18.2%)Gastrocystoplasty with subsequent ileocystoplasty2 (18.2%)Initial composite bladder augmentation with both stomach and ileum5 (45.5%)Multiple augmentations with a final composition of stomach and ileum2 (18.2%) . .

AB - Introduction: Composite bladder augmentation, incorporating gastric and bowel segments, has the theoretical advantage of metabolic neutrality while potentially avoiding the morbidities of gastrocystoplasty, such as hematuria-dysuria syndrome. The most common indication for this operation is a paucity of bowel, such as in cloacal exstrophy. Despite several early descriptive studies of this technique, there are no reports, to date, of long-term follow-up in this population. Objective: To describe the outcomes of composite bladder augmentation utilizing stomach in a cohort of cloacal exstrophy patients. Materials and Methods: A retrospective review of cloacal exstrophy patients who underwent composite bladder augmentation from 1984 to 2006 at two institutions was performed. The incidence of mortality and morbidities related to augmentation was evaluated. Results: Eleven patients with cloacal exstrophy underwent composite bladder augmentation. Median age at initial augmentation was 6.4 years (interquartile range (IQR) 4.4-9.1). Median follow-up was 13.2 years (IQR 11.2-24.6). The Summary table describes the types of composite bladder augmentations. Of the three patients with pre-operative metabolic acidosis, two improved with composite bladder augmentation and one developed metabolic alkalosis. Three developed hematuria-dysuria syndrome: one improved with staged ileocystoplasty, and two had persistent symptoms successfully treated with H2 receptor blockers. Two of 11 developed symptomatic bladder stones. There were no reported bladder perforations, bladder malignancies, conversions to incontinent urinary diversions, or deaths. Conclusion: With long-term follow-up, very few patients developed metabolic acidosis/alkalosis after composite bladder augmentation. The composite bladder augmentation will continue to be used in patients with cloacal exstrophy, in order to minimize the impact on the pre-existing short gut in these patients.Summary tableDescription of the types of composite bladder augmentations.Type of composite bladder augmentationNumber of patients (%)Gastrocystoplasty onto hindgut incorporated during initial bladder closure2 (18.2%)Gastrocystoplasty with subsequent ileocystoplasty2 (18.2%)Initial composite bladder augmentation with both stomach and ileum5 (45.5%)Multiple augmentations with a final composition of stomach and ileum2 (18.2%) . .

KW - Bladder augmentation

KW - Cloacal exstrophy

KW - Gastrocystoplasty

KW - Ileocystoplasty

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