Long-term health experience of jet engine manufacturing workers: II. Total and cause-specific mortality excluding central nervous system neoplasms

Gary M. Marsh, Jeanine M. Buchanich, Ada O. Youk, Michael A. Cunningham, Frank S. Lieberman, Kathleen J. Kennedy, Steven Lacey, Roger P. Hancock, Nurtan A. Esmen

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Objective: Aspart of an exploratory investigation of an unusual occurrence of glioblastoma at one jet engine manufacturing facility located in North Haven, Connecticut (CT), we examined total and cause-specific (excluding central nervous system neoplasms) mortality rates at eight of the company's CT facilities. Methods: Subjects were 223,894 workers ever employed in one or more of the manufacturing facilities from 1952 to 2001. Vital status was determined through 2004 for 99% of subjects and cause of death for 95% of 68,701 deaths. We computed standardized mortality ratios (SMRs) based on US and CT state rates and modeled internal cohort rates. Results: We observed overall deficits in deaths based on national and state comparisons from all causes, all cancers and most of the cause of death categories examined. State comparisons revealed statistically significant excesses in deaths greater than 25% for kidney cancer (68 deaths, SMR = 1.30, CI = 1.01-1.65) and "other non-malignant respiratory disease" (291 deaths, SMR= 1.27, CI= 1.13-1.42) among subjects employed only at North Haven, and for bronchitis (713 deaths, SMR = 1.28, CI = 1.18-1.37) among all hourly workers. These excesses occurred mainly among short-term workers and hourly workers. Conclusions: We found no evidence of elevated mortality risks for all causes combined, all cancers combined and most of the causes of death categories examined. The pattern of findings for kidney cancer, bronchitis and other non-malignant respiratory disease, based on currently available data, suggests these excesses may be due to non-occupational risk factors or to external occupational factors. We will investigate these excesses further when detailed work history and exposure data from the companion exposure assessment project become available.

Original languageEnglish (US)
Pages (from-to)1117-1129
Number of pages13
JournalJournal of Occupational and Environmental Medicine
Volume50
Issue number10
DOIs
StatePublished - Jan 1 2008
Externally publishedYes

Fingerprint

Central Nervous System Neoplasms
Mortality
Health
Cause of Death
Bronchitis
Kidney Neoplasms
Glioblastoma
Neoplasms

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

Cite this

Long-term health experience of jet engine manufacturing workers : II. Total and cause-specific mortality excluding central nervous system neoplasms. / Marsh, Gary M.; Buchanich, Jeanine M.; Youk, Ada O.; Cunningham, Michael A.; Lieberman, Frank S.; Kennedy, Kathleen J.; Lacey, Steven; Hancock, Roger P.; Esmen, Nurtan A.

In: Journal of Occupational and Environmental Medicine, Vol. 50, No. 10, 01.01.2008, p. 1117-1129.

Research output: Contribution to journalArticle

Marsh, Gary M. ; Buchanich, Jeanine M. ; Youk, Ada O. ; Cunningham, Michael A. ; Lieberman, Frank S. ; Kennedy, Kathleen J. ; Lacey, Steven ; Hancock, Roger P. ; Esmen, Nurtan A. / Long-term health experience of jet engine manufacturing workers : II. Total and cause-specific mortality excluding central nervous system neoplasms. In: Journal of Occupational and Environmental Medicine. 2008 ; Vol. 50, No. 10. pp. 1117-1129.
@article{4ec112bae2264d7485b93aba51776bc3,
title = "Long-term health experience of jet engine manufacturing workers: II. Total and cause-specific mortality excluding central nervous system neoplasms",
abstract = "Objective: Aspart of an exploratory investigation of an unusual occurrence of glioblastoma at one jet engine manufacturing facility located in North Haven, Connecticut (CT), we examined total and cause-specific (excluding central nervous system neoplasms) mortality rates at eight of the company's CT facilities. Methods: Subjects were 223,894 workers ever employed in one or more of the manufacturing facilities from 1952 to 2001. Vital status was determined through 2004 for 99{\%} of subjects and cause of death for 95{\%} of 68,701 deaths. We computed standardized mortality ratios (SMRs) based on US and CT state rates and modeled internal cohort rates. Results: We observed overall deficits in deaths based on national and state comparisons from all causes, all cancers and most of the cause of death categories examined. State comparisons revealed statistically significant excesses in deaths greater than 25{\%} for kidney cancer (68 deaths, SMR = 1.30, CI = 1.01-1.65) and {"}other non-malignant respiratory disease{"} (291 deaths, SMR= 1.27, CI= 1.13-1.42) among subjects employed only at North Haven, and for bronchitis (713 deaths, SMR = 1.28, CI = 1.18-1.37) among all hourly workers. These excesses occurred mainly among short-term workers and hourly workers. Conclusions: We found no evidence of elevated mortality risks for all causes combined, all cancers combined and most of the causes of death categories examined. The pattern of findings for kidney cancer, bronchitis and other non-malignant respiratory disease, based on currently available data, suggests these excesses may be due to non-occupational risk factors or to external occupational factors. We will investigate these excesses further when detailed work history and exposure data from the companion exposure assessment project become available.",
author = "Marsh, {Gary M.} and Buchanich, {Jeanine M.} and Youk, {Ada O.} and Cunningham, {Michael A.} and Lieberman, {Frank S.} and Kennedy, {Kathleen J.} and Steven Lacey and Hancock, {Roger P.} and Esmen, {Nurtan A.}",
year = "2008",
month = "1",
day = "1",
doi = "10.1097/JOM.0b013e31818bc327",
language = "English (US)",
volume = "50",
pages = "1117--1129",
journal = "Journal of Occupational and Environmental Medicine",
issn = "1076-2752",
publisher = "Lippincott Williams and Wilkins",
number = "10",

}

TY - JOUR

T1 - Long-term health experience of jet engine manufacturing workers

T2 - II. Total and cause-specific mortality excluding central nervous system neoplasms

AU - Marsh, Gary M.

AU - Buchanich, Jeanine M.

AU - Youk, Ada O.

AU - Cunningham, Michael A.

AU - Lieberman, Frank S.

AU - Kennedy, Kathleen J.

AU - Lacey, Steven

AU - Hancock, Roger P.

AU - Esmen, Nurtan A.

PY - 2008/1/1

Y1 - 2008/1/1

N2 - Objective: Aspart of an exploratory investigation of an unusual occurrence of glioblastoma at one jet engine manufacturing facility located in North Haven, Connecticut (CT), we examined total and cause-specific (excluding central nervous system neoplasms) mortality rates at eight of the company's CT facilities. Methods: Subjects were 223,894 workers ever employed in one or more of the manufacturing facilities from 1952 to 2001. Vital status was determined through 2004 for 99% of subjects and cause of death for 95% of 68,701 deaths. We computed standardized mortality ratios (SMRs) based on US and CT state rates and modeled internal cohort rates. Results: We observed overall deficits in deaths based on national and state comparisons from all causes, all cancers and most of the cause of death categories examined. State comparisons revealed statistically significant excesses in deaths greater than 25% for kidney cancer (68 deaths, SMR = 1.30, CI = 1.01-1.65) and "other non-malignant respiratory disease" (291 deaths, SMR= 1.27, CI= 1.13-1.42) among subjects employed only at North Haven, and for bronchitis (713 deaths, SMR = 1.28, CI = 1.18-1.37) among all hourly workers. These excesses occurred mainly among short-term workers and hourly workers. Conclusions: We found no evidence of elevated mortality risks for all causes combined, all cancers combined and most of the causes of death categories examined. The pattern of findings for kidney cancer, bronchitis and other non-malignant respiratory disease, based on currently available data, suggests these excesses may be due to non-occupational risk factors or to external occupational factors. We will investigate these excesses further when detailed work history and exposure data from the companion exposure assessment project become available.

AB - Objective: Aspart of an exploratory investigation of an unusual occurrence of glioblastoma at one jet engine manufacturing facility located in North Haven, Connecticut (CT), we examined total and cause-specific (excluding central nervous system neoplasms) mortality rates at eight of the company's CT facilities. Methods: Subjects were 223,894 workers ever employed in one or more of the manufacturing facilities from 1952 to 2001. Vital status was determined through 2004 for 99% of subjects and cause of death for 95% of 68,701 deaths. We computed standardized mortality ratios (SMRs) based on US and CT state rates and modeled internal cohort rates. Results: We observed overall deficits in deaths based on national and state comparisons from all causes, all cancers and most of the cause of death categories examined. State comparisons revealed statistically significant excesses in deaths greater than 25% for kidney cancer (68 deaths, SMR = 1.30, CI = 1.01-1.65) and "other non-malignant respiratory disease" (291 deaths, SMR= 1.27, CI= 1.13-1.42) among subjects employed only at North Haven, and for bronchitis (713 deaths, SMR = 1.28, CI = 1.18-1.37) among all hourly workers. These excesses occurred mainly among short-term workers and hourly workers. Conclusions: We found no evidence of elevated mortality risks for all causes combined, all cancers combined and most of the causes of death categories examined. The pattern of findings for kidney cancer, bronchitis and other non-malignant respiratory disease, based on currently available data, suggests these excesses may be due to non-occupational risk factors or to external occupational factors. We will investigate these excesses further when detailed work history and exposure data from the companion exposure assessment project become available.

UR - http://www.scopus.com/inward/record.url?scp=56049091052&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=56049091052&partnerID=8YFLogxK

U2 - 10.1097/JOM.0b013e31818bc327

DO - 10.1097/JOM.0b013e31818bc327

M3 - Article

C2 - 18849757

AN - SCOPUS:56049091052

VL - 50

SP - 1117

EP - 1129

JO - Journal of Occupational and Environmental Medicine

JF - Journal of Occupational and Environmental Medicine

SN - 1076-2752

IS - 10

ER -