Long-term health experience of jet engine manufacturing workers: IV. A comparison of central nervous system cancer ascertainment using mortality and incidence data

Jeanine M. Buchanich, Ada O. Youk, Gary M. Marsh, Kathleen J. Kennedy, Nurtan A. Esmen, Steven E. Lacey, Roger Hancock, Michael A. Cunningham, Frank S. Lieberman, Mary Lou Fleissner

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Purpose: To compare ascertainment of central nervous system (CNS) neoplasms with the use of mortality and incidence data as part of an occupational epidemiology study. Methods: Deaths were identified by matching the cohort of 223,894 jet engine manufacturing employees to the U.S. Social Security Administration death files and the National Death Index. Incident cancer cases were identified by matching the cohort to 19 state cancer registries. Results: We identified 718 cases overall: 59% by the use of both mortality and cancer incidence tracing; 24% by the use of only mortality tracing, and 17% by the use of only cancer incidence tracing. Compared with state cancer registries, death certificates missed 38% of the malignant, more than six times the benign and nearly 1.5 times the unspecified CNS cases. The positive predictive value of death certificates, with cancer registry as gold standard, was 6% for unspecified, 35% for benign, and 86% for malignant histologies. Conclusions: Death certificates seriously underascertained benign and unspecified CNS tumors; analyses determined with mortality data would not accurately capture the true extent of disease among the cohort. Most state cancer registries have only collected nonmalignant CNS tumor information since 2004, which currently limits the usefulness of state cancer registries as a source of nonmalignant CNS tumor identification. Underascertainment of CNS deaths could seriously affect interpretation of results, more so if examining nonmalignant CNS.

Original languageEnglish (US)
Pages (from-to)759-765
Number of pages7
JournalAnnals of Epidemiology
Volume20
Issue number10
DOIs
StatePublished - Oct 2010
Externally publishedYes

Keywords

  • Brain Cancer
  • Cancer Incidence
  • Central Nervous System Neoplasms
  • Death Certificates
  • Methodology
  • Mortality

ASJC Scopus subject areas

  • Epidemiology

Fingerprint Dive into the research topics of 'Long-term health experience of jet engine manufacturing workers: IV. A comparison of central nervous system cancer ascertainment using mortality and incidence data'. Together they form a unique fingerprint.

  • Cite this

    Buchanich, J. M., Youk, A. O., Marsh, G. M., Kennedy, K. J., Esmen, N. A., Lacey, S. E., Hancock, R., Cunningham, M. A., Lieberman, F. S., & Fleissner, M. L. (2010). Long-term health experience of jet engine manufacturing workers: IV. A comparison of central nervous system cancer ascertainment using mortality and incidence data. Annals of Epidemiology, 20(10), 759-765. https://doi.org/10.1016/j.annepidem.2010.06.008