Long-term health experience of jet engine manufacturing workers: III. Incidence of malignant central nervous system neoplasms

Gary M. Marsh, Jeanine M. Buchanich, Ada O. Youk, Michael A. Cunningham, Frank S. Lieberman, Kathleen J. Kennedy, Steven E. Lacey, Roger P. Hancock, Nurtan A. Esmen, Mary Lou Fleissner

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Objective: To explore a perceived unusual occurrence of glioblastoma at one jet engine manufacturing facility located in North Haven (NH), Connecticut (CT). Methods: Subjects were 212,513 workers ever employed in 1 of 8 manufacturing facilities from 1952 to 2001 and at risk from 1976 to 2004. We identified 722 cases of CNS neoplasms mainly by tracing through 19 state cancer registries. We computed standardized incidence ratios (SIRs) based on CT state and national rates and modeled internal relative risks (RRs). Results: We found overall deficits in cases for glioblastoma (275 cases, SIR = 0.77, CI = 0.68-0.87) and most other histology categories examined. NH workers had a not statistically significant overall 8% excess in glioblastoma (43 cases, SIR = 1.08, CI = 0.78-1.46). Salaried NH workers had a statistically significant twofold risk of glioblastoma compared with hourly workers (17 cases, RR = 2.04, CI = 1.15-3.57). Other subgroups of NH workers revealed elevated but not statistically significant glioblastoma risks but little evidence of an association with duration of employment or time since first employment. Conclusions: Incidence rates for glioblastoma and other malignant CNS neoplasm histologies were not elevated in the total cohort. The glioblastoma excesses observed among NH workers may reflect external occupational factors, non-occupational factors or workplace factors unique to NH unmeasured in the current study.

Original languageEnglish (US)
Pages (from-to)123-141
Number of pages19
JournalNeuroepidemiology
Volume35
Issue number2
DOIs
StatePublished - Aug 1 2010

Fingerprint

Central Nervous System Neoplasms
Glioblastoma
Incidence
Health
Histology
Neoplasms
Workplace
Registries

Keywords

  • Cancer incidence
  • Central nervous system neoplasms
  • Cohort study
  • Jet engine manufacturing

ASJC Scopus subject areas

  • Epidemiology
  • Clinical Neurology

Cite this

Marsh, G. M., Buchanich, J. M., Youk, A. O., Cunningham, M. A., Lieberman, F. S., Kennedy, K. J., ... Fleissner, M. L. (2010). Long-term health experience of jet engine manufacturing workers: III. Incidence of malignant central nervous system neoplasms. Neuroepidemiology, 35(2), 123-141. https://doi.org/10.1159/000310348

Long-term health experience of jet engine manufacturing workers : III. Incidence of malignant central nervous system neoplasms. / Marsh, Gary M.; Buchanich, Jeanine M.; Youk, Ada O.; Cunningham, Michael A.; Lieberman, Frank S.; Kennedy, Kathleen J.; Lacey, Steven E.; Hancock, Roger P.; Esmen, Nurtan A.; Fleissner, Mary Lou.

In: Neuroepidemiology, Vol. 35, No. 2, 01.08.2010, p. 123-141.

Research output: Contribution to journalArticle

Marsh, GM, Buchanich, JM, Youk, AO, Cunningham, MA, Lieberman, FS, Kennedy, KJ, Lacey, SE, Hancock, RP, Esmen, NA & Fleissner, ML 2010, 'Long-term health experience of jet engine manufacturing workers: III. Incidence of malignant central nervous system neoplasms', Neuroepidemiology, vol. 35, no. 2, pp. 123-141. https://doi.org/10.1159/000310348
Marsh, Gary M. ; Buchanich, Jeanine M. ; Youk, Ada O. ; Cunningham, Michael A. ; Lieberman, Frank S. ; Kennedy, Kathleen J. ; Lacey, Steven E. ; Hancock, Roger P. ; Esmen, Nurtan A. ; Fleissner, Mary Lou. / Long-term health experience of jet engine manufacturing workers : III. Incidence of malignant central nervous system neoplasms. In: Neuroepidemiology. 2010 ; Vol. 35, No. 2. pp. 123-141.
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