Long-term health experience of jet engine manufacturing workers: VI: Incidence of malignant central nervous system neoplasms in relation to estimated workplace exposures

Gary M. Marsh, Ada O. Youk, Jeanine M. Buchanich, Hui Xu, Sarah Downing, Kathleen J. Kennedy, Nurtan A. Esmen, Roger P. Hancock, Steven Lacey, Mary Lou Fleissner

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Objective: To determine whether glioblastoma (GB) incidence rates among jet engine manufacturing workers were associated with specific chemical or physical exposures. Methods: Subjects were 210,784 workers employed from 1952 to 2001. We conducted a cohort incidence study and two nested case-control studies with focus on the North Haven facility where we previously observed a not statistically significant overall elevation in GB rates. We estimated individual-level exposure metrics for 11 agents. Results: In the total cohort, none of the agent metrics considered was associated with increased GB risk. The GB incidence rates in North Haven were also not related to workplace exposures, including the "blue haze" exposure unique to North Haven. Conclusions: If not due to chance alone, GB rates in North Haven may reflect external occupational factors, nonoccupational factors, or workplace factors unique to North Haven unmeasured in the current evaluation.

Original languageEnglish (US)
Pages (from-to)654-675
Number of pages22
JournalJournal of Occupational and Environmental Medicine
Volume55
Issue number6
DOIs
StatePublished - Jun 1 2013
Externally publishedYes

Fingerprint

Central Nervous System Neoplasms
Glioblastoma
Workplace
Incidence
Health
Cohort Studies
Case-Control Studies

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

Cite this

Long-term health experience of jet engine manufacturing workers : VI: Incidence of malignant central nervous system neoplasms in relation to estimated workplace exposures. / Marsh, Gary M.; Youk, Ada O.; Buchanich, Jeanine M.; Xu, Hui; Downing, Sarah; Kennedy, Kathleen J.; Esmen, Nurtan A.; Hancock, Roger P.; Lacey, Steven; Fleissner, Mary Lou.

In: Journal of Occupational and Environmental Medicine, Vol. 55, No. 6, 01.06.2013, p. 654-675.

Research output: Contribution to journalArticle

Marsh, Gary M. ; Youk, Ada O. ; Buchanich, Jeanine M. ; Xu, Hui ; Downing, Sarah ; Kennedy, Kathleen J. ; Esmen, Nurtan A. ; Hancock, Roger P. ; Lacey, Steven ; Fleissner, Mary Lou. / Long-term health experience of jet engine manufacturing workers : VI: Incidence of malignant central nervous system neoplasms in relation to estimated workplace exposures. In: Journal of Occupational and Environmental Medicine. 2013 ; Vol. 55, No. 6. pp. 654-675.
@article{f2b97c4561a44a56bde97ede14f7d18f,
title = "Long-term health experience of jet engine manufacturing workers: VI: Incidence of malignant central nervous system neoplasms in relation to estimated workplace exposures",
abstract = "Objective: To determine whether glioblastoma (GB) incidence rates among jet engine manufacturing workers were associated with specific chemical or physical exposures. Methods: Subjects were 210,784 workers employed from 1952 to 2001. We conducted a cohort incidence study and two nested case-control studies with focus on the North Haven facility where we previously observed a not statistically significant overall elevation in GB rates. We estimated individual-level exposure metrics for 11 agents. Results: In the total cohort, none of the agent metrics considered was associated with increased GB risk. The GB incidence rates in North Haven were also not related to workplace exposures, including the {"}blue haze{"} exposure unique to North Haven. Conclusions: If not due to chance alone, GB rates in North Haven may reflect external occupational factors, nonoccupational factors, or workplace factors unique to North Haven unmeasured in the current evaluation.",
author = "Marsh, {Gary M.} and Youk, {Ada O.} and Buchanich, {Jeanine M.} and Hui Xu and Sarah Downing and Kennedy, {Kathleen J.} and Esmen, {Nurtan A.} and Hancock, {Roger P.} and Steven Lacey and Fleissner, {Mary Lou}",
year = "2013",
month = "6",
day = "1",
doi = "10.1097/JOM.0b013e3182749c4a",
language = "English (US)",
volume = "55",
pages = "654--675",
journal = "Journal of Occupational and Environmental Medicine",
issn = "1076-2752",
publisher = "Lippincott Williams and Wilkins",
number = "6",

}

TY - JOUR

T1 - Long-term health experience of jet engine manufacturing workers

T2 - VI: Incidence of malignant central nervous system neoplasms in relation to estimated workplace exposures

AU - Marsh, Gary M.

AU - Youk, Ada O.

AU - Buchanich, Jeanine M.

AU - Xu, Hui

AU - Downing, Sarah

AU - Kennedy, Kathleen J.

AU - Esmen, Nurtan A.

AU - Hancock, Roger P.

AU - Lacey, Steven

AU - Fleissner, Mary Lou

PY - 2013/6/1

Y1 - 2013/6/1

N2 - Objective: To determine whether glioblastoma (GB) incidence rates among jet engine manufacturing workers were associated with specific chemical or physical exposures. Methods: Subjects were 210,784 workers employed from 1952 to 2001. We conducted a cohort incidence study and two nested case-control studies with focus on the North Haven facility where we previously observed a not statistically significant overall elevation in GB rates. We estimated individual-level exposure metrics for 11 agents. Results: In the total cohort, none of the agent metrics considered was associated with increased GB risk. The GB incidence rates in North Haven were also not related to workplace exposures, including the "blue haze" exposure unique to North Haven. Conclusions: If not due to chance alone, GB rates in North Haven may reflect external occupational factors, nonoccupational factors, or workplace factors unique to North Haven unmeasured in the current evaluation.

AB - Objective: To determine whether glioblastoma (GB) incidence rates among jet engine manufacturing workers were associated with specific chemical or physical exposures. Methods: Subjects were 210,784 workers employed from 1952 to 2001. We conducted a cohort incidence study and two nested case-control studies with focus on the North Haven facility where we previously observed a not statistically significant overall elevation in GB rates. We estimated individual-level exposure metrics for 11 agents. Results: In the total cohort, none of the agent metrics considered was associated with increased GB risk. The GB incidence rates in North Haven were also not related to workplace exposures, including the "blue haze" exposure unique to North Haven. Conclusions: If not due to chance alone, GB rates in North Haven may reflect external occupational factors, nonoccupational factors, or workplace factors unique to North Haven unmeasured in the current evaluation.

UR - http://www.scopus.com/inward/record.url?scp=84879183915&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84879183915&partnerID=8YFLogxK

U2 - 10.1097/JOM.0b013e3182749c4a

DO - 10.1097/JOM.0b013e3182749c4a

M3 - Article

C2 - 23715109

AN - SCOPUS:84879183915

VL - 55

SP - 654

EP - 675

JO - Journal of Occupational and Environmental Medicine

JF - Journal of Occupational and Environmental Medicine

SN - 1076-2752

IS - 6

ER -