Abstract
Our aim was to study the long-term outcomes of all transplant recipients who underwent angiography for suspected TRAS at our institution. The patients were divided into TRAS+ve and TRAS-ve groups based upon angiographically confirmed results. TRAS was confirmed in 58.1% of 74 patients with median time of 8.9 months. Primary angioplasty alone was performed in 56% of patients with TRAS, while the remaining had PTA with stent (PTAS). There was reduction in systolic and diastolic BP (165 ± 19-136 ± 15 mmHg and 82 ± 14 mmHg to 68 ± 12 mmHg; p < 0.05) and number of antihypertensive drugs (3.5 ± 0.9-2.7 ± 1.0; p < 0.05). Overall, graft survival and patient survival from time of transplant were similar in both groups. Graft function was similar for the patients with treated TRAS+ve as compared to TRAS-ve over time. Graft survival and patient survival when compared to an age- and year of transplant-matched cohort control group were also similar. In conclusion, angiography for suspected TRAS is more likely to yield a confirmatory result early in the transplant course as compared to late. Treatment of TRAS in these patients had sustained long-term graft function. Alternative etiologies of HTN and graft dysfunction should be sought for recipients further out from transplant.
| Original language | English |
|---|---|
| Pages (from-to) | 747-755 |
| Number of pages | 9 |
| Journal | Clinical Transplantation |
| Volume | 29 |
| Issue number | 9 |
| DOIs | |
| State | Published - Sep 1 2015 |
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Keywords
- Graft function
- Graft survival
- Hypertension
- Kidney transplant
- Transplant renal artery stenosis
ASJC Scopus subject areas
- Transplantation
Cite this
Long-term outcomes of transplant recipients referred for angiography for suspected transplant renal artery stenosis. / Ali, Anum; Mishler, Dennis; Taber, Tim; Agarwal, David; Yaqub, Muhammad; Mujtaba, Muhammad; Goggins, William; Sharfuddin, Asif.
In: Clinical Transplantation, Vol. 29, No. 9, 01.09.2015, p. 747-755.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Long-term outcomes of transplant recipients referred for angiography for suspected transplant renal artery stenosis
AU - Ali, Anum
AU - Mishler, Dennis
AU - Taber, Tim
AU - Agarwal, David
AU - Yaqub, Muhammad
AU - Mujtaba, Muhammad
AU - Goggins, William
AU - Sharfuddin, Asif
PY - 2015/9/1
Y1 - 2015/9/1
N2 - Our aim was to study the long-term outcomes of all transplant recipients who underwent angiography for suspected TRAS at our institution. The patients were divided into TRAS+ve and TRAS-ve groups based upon angiographically confirmed results. TRAS was confirmed in 58.1% of 74 patients with median time of 8.9 months. Primary angioplasty alone was performed in 56% of patients with TRAS, while the remaining had PTA with stent (PTAS). There was reduction in systolic and diastolic BP (165 ± 19-136 ± 15 mmHg and 82 ± 14 mmHg to 68 ± 12 mmHg; p < 0.05) and number of antihypertensive drugs (3.5 ± 0.9-2.7 ± 1.0; p < 0.05). Overall, graft survival and patient survival from time of transplant were similar in both groups. Graft function was similar for the patients with treated TRAS+ve as compared to TRAS-ve over time. Graft survival and patient survival when compared to an age- and year of transplant-matched cohort control group were also similar. In conclusion, angiography for suspected TRAS is more likely to yield a confirmatory result early in the transplant course as compared to late. Treatment of TRAS in these patients had sustained long-term graft function. Alternative etiologies of HTN and graft dysfunction should be sought for recipients further out from transplant.
AB - Our aim was to study the long-term outcomes of all transplant recipients who underwent angiography for suspected TRAS at our institution. The patients were divided into TRAS+ve and TRAS-ve groups based upon angiographically confirmed results. TRAS was confirmed in 58.1% of 74 patients with median time of 8.9 months. Primary angioplasty alone was performed in 56% of patients with TRAS, while the remaining had PTA with stent (PTAS). There was reduction in systolic and diastolic BP (165 ± 19-136 ± 15 mmHg and 82 ± 14 mmHg to 68 ± 12 mmHg; p < 0.05) and number of antihypertensive drugs (3.5 ± 0.9-2.7 ± 1.0; p < 0.05). Overall, graft survival and patient survival from time of transplant were similar in both groups. Graft function was similar for the patients with treated TRAS+ve as compared to TRAS-ve over time. Graft survival and patient survival when compared to an age- and year of transplant-matched cohort control group were also similar. In conclusion, angiography for suspected TRAS is more likely to yield a confirmatory result early in the transplant course as compared to late. Treatment of TRAS in these patients had sustained long-term graft function. Alternative etiologies of HTN and graft dysfunction should be sought for recipients further out from transplant.
KW - Graft function
KW - Graft survival
KW - Hypertension
KW - Kidney transplant
KW - Transplant renal artery stenosis
UR - http://www.scopus.com/inward/record.url?scp=84940927816&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84940927816&partnerID=8YFLogxK
U2 - 10.1111/ctr.12574
DO - 10.1111/ctr.12574
M3 - Article
C2 - 26052624
AN - SCOPUS:84940927816
VL - 29
SP - 747
EP - 755
JO - Clinical Transplantation
JF - Clinical Transplantation
SN - 0902-0063
IS - 9
ER -