Long-term results in combined-modality treatment of small cell carcinoma of the lung

L. H. Einhorn, W. H. Bond, N. Hornback, B. T. Joe

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87 Scopus citations


Fifty-eight patients with small cell carcinoma of the lung were treated with a combined-modality regimen: chemotherapy with adriamycin, cyclophosphamide, and vincristine; BCG immunotherapy; radiotherapy to the lung primary and prophylactic cranial irradiation. Nineteen patients had limited disease, and 39 had extensive disease. There were 27 (48%) partial remissions and 23 (41%) complete remissions, and median survival was 51 wk. Initial performance status and extent of disease had a definite effect on survival. Only 1 patient developed CNS metastases on prophylactic cranial irradiation. Five of 19 patients (26%) with limited disease remain alive and in complete remission at 26-45+ mo. It is becoming clear from this and other recent studies that we can significantly prolong median survival in small cell lung cancer. However, even more important is the fact that limited-extent small cell lung cancer may be a potentially curable disease.

Original languageEnglish (US)
Pages (from-to)309-313
Number of pages5
JournalSeminars in oncology
Issue number3
StatePublished - Dec 1 1978

ASJC Scopus subject areas

  • Hematology
  • Oncology

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