Long-term safety and efficacy of stereotactic body radiation therapy for hepatic oligometastases

Benjamin D. Goodman, Edward M. Mannina, Sandra K. Althouse, Mary Maluccio, Higinia R. Cárdenes

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

Purpose: To evaluate long-term outcome and toxicity of stereotactic body radiation therapy (SBRT) for hepatic oligometastases from solid tumors. Methods and materials: Eligible patients had 1 to 3 liver metastases, maximum sum diameter 6 cm, without extrahepatic progression. We treated 106 lesions in 81 patients; 67% with colorectal primaries. Median dose was 5400 cGy in 3 to 5 fractions. Results: At median follow-up of 33 months (2.5-70 months), overall local control was 94% (95% confidence interval, not estimable); Kaplan-Meier estimated 96% at 1 year and 91% at 2, 3, and 4 years. Partial/complete response was observed in 69% of lesions with less than 3% progressing. Median survival time was 33.6 months (95% confidence interval, 29.1-38.4); Kaplan-Meier survival estimates at 1, 2, 3, and 4 years were 89.9%, 68.6%, 44.0%, and 28.0%, respectively. Grade 3 or greater liver toxicity was 4.9%. Conclusion: SBRT is effective for selected patients with hepatic oligometastases with limited toxicities. A phase 3 trial comparing SBRT with "gold-standard" surgical resection is warranted.

Original languageEnglish (US)
Pages (from-to)86-95
Number of pages10
JournalPractical Radiation Oncology
Volume6
Issue number2
DOIs
StatePublished - Mar 1 2016

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging

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