Long term survival after lung transplantation: A single center experience

David Blitzer, Hannah Copeland, David Roe, Chadi Hage, I. Wen Wang, Michael Duncan, Joshua Manghelli, Danyel Gooch, Thomas Wozniak

Research output: Contribution to journalArticle

Abstract

Background: There are approximately 2000 lung transplants performed across the United States annually. There is limited data to identify factors predictive of long-term survival. Objective: We evaluated 10-year survivors after lung transplant to determine predictors of long-term survival. Methods: Data were collected from the United Network for Organ Sharing registry database from a single institution. Inclusion criteria were: patients who received a lung transplant between 1989 and 2005. Descriptive statistics were calculated, and survival outcomes were analyzed using the Kaplan-Meier method. Results: Three hundred sixty-one patients received a lung transplant between 1989 and 2005, and 77 patients survived at least 10 years (21%). Diagnoses at the time of transplant included: chronic obstructive pulmonary disease/emphysema 45 (58.4%), idiopathic pulmonary fibrosis 12 (15.6%), alpha 1 anti-trypsin deficiency 6 (7.8%), cystic fibrosis 4 (5.2%), primary pulmonary hypertension 2 (2.6%), and Eisenmenger's syndrome 1 (1.3%). Seventy-four recipients (96.10%) were Caucasian; 46 (59.74%) were female. Age at the time of transplant ranged from 19 to 67 years (mean 50.8; median 52). Forty-two patients (54.5%) were double lung recipients. Survival ranged from 10.0 to 21.9 years (mean 15.5y; median 15.48y). Forty-two (54.5%) subjects are currently alive; the most common causes of death included: chronic rejection (20%), and infection (17.14%). Conclusions: Ten-year survivors were significantly younger, weighed less, and had significantly shorter lengths of hospitalization after transplantation. Bilateral lung transplantation was a significant factor in prolonged survival. Survival also improved with institutional experience.

Original languageEnglish (US)
Pages (from-to)273-278
Number of pages6
JournalJournal of Cardiac Surgery
Volume35
Issue number2
DOIs
StatePublished - Feb 1 2020

Keywords

  • clinical review
  • transplant

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

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    Blitzer, D., Copeland, H., Roe, D., Hage, C., Wang, I. W., Duncan, M., Manghelli, J., Gooch, D., & Wozniak, T. (2020). Long term survival after lung transplantation: A single center experience. Journal of Cardiac Surgery, 35(2), 273-278. https://doi.org/10.1111/jocs.14163