Long-term survival after traumatic brain injury: A population-based analysis

Allen W. Brown, Cynthia L. Leibson, James F. Malec, Patricia K. Perkins, Nancy N. Diehl, Dirk R. Larson

Research output: Contribution to journalArticle

97 Citations (Scopus)

Abstract

This population-based retrospective cohort study identified all Olmsted County, MN residents with any diagnosis indicative of potential traumatic brain injury (TBI) during the years 1985 to 2000. The complete community-based medical records of a random sample (n = 7,175) were reviewed to confirm and characterize the event, and to determine vital status through 2002. The review identified 1,448 confirmed incident cases; 164 (11%) were moderate to severe; 1,284 were mild. The estimated 30-day case fatality rate was 29% for moderate to severe cases and 0.2% for mild cases. Comparison of observed mortality over the full period of follow-up with that expected revealed a risk ratio (95% CI) of 5.29 (4.11-6.71) for moderate to severe cases and 1.33 (1.05-1.65) for mild cases. Proportional hazards modeling showed the adjusted hazard of all-cause mortality for moderate to severe cases relative to mild cases was 5.18 (3.65-7.3) within six months of the event and 1.04 (0.57-1.88) for the remaining follow-up period. This analysis indicates that persons who experience mild TBI exhibit a small but statistically significant reduction in long-term survival compared to the general population. The case fatality rate for persons with moderate to severe TBI is very high, but among six-month survivors, long-term survival is similar to that for persons with mild TBI.

Original languageEnglish (US)
Pages (from-to)37-43
Number of pages7
JournalNeuroRehabilitation
Volume19
Issue number1
StatePublished - 2004
Externally publishedYes

Fingerprint

Brain Concussion
Survival
Mortality
Population
Medical Records
Survivors
Cohort Studies
Retrospective Studies
Odds Ratio
Traumatic Brain Injury

Keywords

  • Brain injuries
  • Head trauma
  • Longevity
  • Mortality

ASJC Scopus subject areas

  • Rehabilitation
  • Clinical Neurology
  • Health Professions(all)

Cite this

Brown, A. W., Leibson, C. L., Malec, J. F., Perkins, P. K., Diehl, N. N., & Larson, D. R. (2004). Long-term survival after traumatic brain injury: A population-based analysis. NeuroRehabilitation, 19(1), 37-43.

Long-term survival after traumatic brain injury : A population-based analysis. / Brown, Allen W.; Leibson, Cynthia L.; Malec, James F.; Perkins, Patricia K.; Diehl, Nancy N.; Larson, Dirk R.

In: NeuroRehabilitation, Vol. 19, No. 1, 2004, p. 37-43.

Research output: Contribution to journalArticle

Brown, AW, Leibson, CL, Malec, JF, Perkins, PK, Diehl, NN & Larson, DR 2004, 'Long-term survival after traumatic brain injury: A population-based analysis', NeuroRehabilitation, vol. 19, no. 1, pp. 37-43.
Brown AW, Leibson CL, Malec JF, Perkins PK, Diehl NN, Larson DR. Long-term survival after traumatic brain injury: A population-based analysis. NeuroRehabilitation. 2004;19(1):37-43.
Brown, Allen W. ; Leibson, Cynthia L. ; Malec, James F. ; Perkins, Patricia K. ; Diehl, Nancy N. ; Larson, Dirk R. / Long-term survival after traumatic brain injury : A population-based analysis. In: NeuroRehabilitation. 2004 ; Vol. 19, No. 1. pp. 37-43.
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