Long-term Survival with Paclitaxel and Gemcitabine for Germ Cell Tumors after Progression Following High-Dose Chemotherapy with Tandem Transplant

Brian P. Mulherin, Mary J. Brames, Lawrence H. Einhorn

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Objectives: Germ cell tumor patients progressing after high-dose chemotherapy (HDCT) have a dismal prognosis. A prior retrospective study of paclitaxel and gemcitabine enrolled 32 patients. All failed first-line chemotherapy and salvage therapy with HDCT. We now present long-term results. Methods: Eligible patients received BEP or similar first-line chemotherapy and subsequent HDCT. They were treated with paclitaxel (100 mg/m 2) on days 1, 8, and 15 and gemcitabine (1000 mg/m 2) on days 1, 8, and 15 every 4 weeks for a maximum of 6 cycles. Results: Ten of 32 (31%) had an objective response (4 partial remissions and 6 complete responses). Four patients (12.5% of total) have enjoyed long-term survival; 3 are continuously disease free for 64, 94, and 122 months. None of these 3 received subsequent chemotherapy or surgery. A fourth patient relapsed after 72 months, and has now reachieved remission for 36+ months after treatment with the same regimen. These patients had 2, 2, 2, and 4 prior therapies, respectively, and a rising serum human chorionic gonadotropin (69 and 138 mIU/mL), α-fetoprotein (525 ng/mL), or increasing intrathoracic metastases. Longest prior response ranged from 5 to 24 months. Conclusions: Paclitaxel and gemcitabine salvage chemotherapy can offer long-term survival and probable cure in relapsed/refractory germ cell tumor patients after HDCT. This is an appropriate regimen in a taxane-naive and gemcitabine-naive patient population. This is the first example of a nonplatinum curative chemotherapy regimen in patients progressing after HDCT.

Original languageEnglish (US)
Pages (from-to)373-376
Number of pages4
JournalAmerican Journal of Clinical Oncology: Cancer Clinical Trials
Volume38
Issue number4
DOIs
StatePublished - Aug 6 2015

Keywords

  • gemcitabine
  • germ cell
  • paclitaxel
  • transplants

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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