Long-term treatment with recombinant nerve growth factor for HIV-associated sensory neuropathy

Giovanni Schifitto, C. Yiannoutsos, D. M. Simpson, B. T. Adornato, E. J. Singer, H. Hollander, C. M. Marra, M. Rubin, B. A. Cohen, T. Tucker, I. J. Koralnik, D. Katzenstein, B. Haidich, M. E. Smith, S. Shriver, L. Millar, D. B. Clifford, J. C. McArthur

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92 Scopus citations

Abstract

HIV-associated distal sensory polyneuropathy (DSP) is a common complication of AIDS. No effective treatment is available. The authors investigated the long-term effect (48 weeks) of the neurotrophin nerve growth factor (NGF) in an open-label study of 200 subjects with HIV-associated DSP. Similar to their previously reported double-blind study, the authors showed that NGF was safe and well tolerated and significantly improved pain symptoms. However, there was no improvement of neuropathy severity as assessed by neurologic examination, quantitative sensory testing, and epidermal nerve fiber density.

Original languageEnglish (US)
Pages (from-to)1313-1316
Number of pages4
JournalNeurology
Volume57
Issue number7
DOIs
StatePublished - Oct 9 2001
Externally publishedYes

ASJC Scopus subject areas

  • Clinical Neurology

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    Schifitto, G., Yiannoutsos, C., Simpson, D. M., Adornato, B. T., Singer, E. J., Hollander, H., Marra, C. M., Rubin, M., Cohen, B. A., Tucker, T., Koralnik, I. J., Katzenstein, D., Haidich, B., Smith, M. E., Shriver, S., Millar, L., Clifford, D. B., & McArthur, J. C. (2001). Long-term treatment with recombinant nerve growth factor for HIV-associated sensory neuropathy. Neurology, 57(7), 1313-1316. https://doi.org/10.1212/WNL.57.7.1313