Long-term tumor resistance induced by laser photo-immunotherapy

Wei R. Chen, Wei Guo Zhu, Joseph Dynlacht, Hong Liu, Robert E. Nordquist

Research output: Contribution to journalArticle

129 Citations (Scopus)

Abstract

An ideal treatment modality for metastasizing tumors should eradicate the primary tumor and elicit a systemic, tumor-selective response leading to elimination of metastases and long-term tumor resistance. Also, it should be induced by local treatment at the primary site, to limit adverse systemic effects. A new method for treating metastatic tumors which utilizes a combination of a near-infrared laser, a photosensitizer and an immunoadjuvant has been developed. It involves intra-tumor injection of the sensitizer/adjuvant solution, followed by local non-invasive laser irradiation. It has produced regression and total eradication of treated primary tumors and untreated metastases at remote sites against mammary tumors in rats. Successfully treated tumor-bearing rats showed total tumor resistance to subsequent tumor rechallenge. Our histochemical results showed that sera from cured tumor-bearing rats contained antibodies that bound strongly to the plasma membrane of both living and preserved tumor cells. Western blot analysis of tumor cell proteins using sera from successfully treated rats as the source of primary antibodies also showed distinct bands, indicating induction of tumor-selective antibodies. Our findings indicate that a systemic, long-term effect on metastatic tumors can be induced by local application of laser photo-immunotherapy.

Original languageEnglish (US)
Pages (from-to)808-812
Number of pages5
JournalInternational Journal of Cancer
Volume81
Issue number5
DOIs
StatePublished - 1999
Externally publishedYes

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Immunotherapy
Lasers
Neoplasms
Neoplasm Metastasis
Neoplasm Antibodies
Immunologic Adjuvants
Photosensitizing Agents
Antibodies
Blood Proteins
Western Blotting
Cell Membrane
Breast Neoplasms

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Long-term tumor resistance induced by laser photo-immunotherapy. / Chen, Wei R.; Zhu, Wei Guo; Dynlacht, Joseph; Liu, Hong; Nordquist, Robert E.

In: International Journal of Cancer, Vol. 81, No. 5, 1999, p. 808-812.

Research output: Contribution to journalArticle

Chen, Wei R. ; Zhu, Wei Guo ; Dynlacht, Joseph ; Liu, Hong ; Nordquist, Robert E. / Long-term tumor resistance induced by laser photo-immunotherapy. In: International Journal of Cancer. 1999 ; Vol. 81, No. 5. pp. 808-812.
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