Long-term use of medications and destructive periodontal disease

Philippe P. Hujoel, Joana Cunha-Cruz, Gerardo Maupome, Barry Saver

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background: Knowledge of typical medication use among patients with chronic periodontitis or destructive periodontal disease is limited. The aim of this study was to associate periodontitis severity with the use of different classes of medications. Methods: Patients (N = 12,631) who had medical, dental, and pharmaceutical coverage with a health maintenance organization and whose severity of destructive periodontal disease was diagnosed by a dentist or specialist were included in the study. The rate of drug use over 7 years was related to the severity of destructive periodontal disease by means of Poisson regression models. Results: Individuals with moderate to advanced periodontitis had significantly lower fill rates for the respiratory agents (antihistamines: -23%, 95% confidence interval [CI]: -10% to -34%; decongestants: -24%, 95% CI: -13% to -34%; and cough/cold medications: -12%, 95% CI: -3% to -21%) and anti-infective agents (antibiotics: -12%, 95% confidence interval: -6% to -18%; urinary anti-infectives: -36%, 95% CI: -6% to -56%; and topical antibiotics: -18%, 95% CI: -5% to -29%). Conclusions: More severe periodontitis was a marker for reduced medication use for allergies and infections. The associations between destructive periodontal disease, infections, allergies, and the hygiene hypothesis need further exploration.

Original languageEnglish (US)
Pages (from-to)1330-1338
Number of pages9
JournalJournal of Periodontology
Volume79
Issue number8
DOIs
StatePublished - Aug 2008

Fingerprint

Periodontal Diseases
Confidence Intervals
Periodontitis
Dental Pharmaceutical Preparations
Hypersensitivity
Hygiene Hypothesis
Nasal Decongestants
Anti-Bacterial Agents
Chronic Periodontitis
Health Maintenance Organizations
Histamine Antagonists
Respiratory Rate
Anti-Infective Agents
Infection
Dentists
Cough
Pharmaceutical Preparations

Keywords

  • Allergies
  • Drug prescriptions
  • Infections

ASJC Scopus subject areas

  • Dentistry(all)

Cite this

Long-term use of medications and destructive periodontal disease. / Hujoel, Philippe P.; Cunha-Cruz, Joana; Maupome, Gerardo; Saver, Barry.

In: Journal of Periodontology, Vol. 79, No. 8, 08.2008, p. 1330-1338.

Research output: Contribution to journalArticle

Hujoel, Philippe P. ; Cunha-Cruz, Joana ; Maupome, Gerardo ; Saver, Barry. / Long-term use of medications and destructive periodontal disease. In: Journal of Periodontology. 2008 ; Vol. 79, No. 8. pp. 1330-1338.
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