Long-term virologic and immunologic responses in human immunodeficiency virus type 1-infected children treated with indinavir, zidovudine, and lamivudine

Shirley Jankelevich, Brigitta U. Mueller, Crystal L. Mackall, Sharon Smith, Sheryl Zwerski, Lauren V. Wood, Steven L. Zeichner, Leslie Serchuck, Seth M. Steinberg, Robert P. Nelson, John W. Sleasman, Bach Yen Nguyen, Philip A. Pizzo, Robert Yarchoan

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

Virologic and immunologic responses were examined for 33 human immunodeficiency virus (HIV)-infected children who participated for ≥96 weeks in a phase 1/2 protocol of 16 weeks of indinavir monotherapy, followed by the addition of zidovudine and lamivudine. At week 96, a median increase of 199 CD4+T cells/μL and a median decrease of 0.74 log10HIV RNA copies/mL were observed. The relationship between control of viral replication and CD4+T cell count was examined. Patients were categorized into 3 response groups on the basis of duration and extent of control of viral replication. Of 21 children with a transient decrease in virus load of ≥0.7 log10HIV RNA copies/mL from baseline, 7 experienced sustained increases in CD4+, CD4+CD45RA+, and CD4+CD45RO+T cell counts. CD4+CD45RA+(naive) T cells were the major contributor to CD4+T cell expansion. Continued long-term immunologic benefit may be experienced by a subset of children, despite only transient virologic suppression.

Original languageEnglish (US)
Pages (from-to)1116-1120
Number of pages5
JournalJournal of Infectious Diseases
Volume183
Issue number7
DOIs
StatePublished - Apr 1 2001

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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    Jankelevich, S., Mueller, B. U., Mackall, C. L., Smith, S., Zwerski, S., Wood, L. V., Zeichner, S. L., Serchuck, L., Steinberg, S. M., Nelson, R. P., Sleasman, J. W., Nguyen, B. Y., Pizzo, P. A., & Yarchoan, R. (2001). Long-term virologic and immunologic responses in human immunodeficiency virus type 1-infected children treated with indinavir, zidovudine, and lamivudine. Journal of Infectious Diseases, 183(7), 1116-1120. https://doi.org/10.1086/319274