Longitudinal analyses of early lesions by fluorescence

an observational study.

A. Ferreira Zandoná, Masatoshi Ando, G. F. Gomez, M. Garcia-Corretjer, G. J. Eckert, E. Santiago, Barry Katz, Domenick Zero

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Previous caries experience correlates to future caries risk; thus, early identification of lesions has importance for risk assessment and management. In this study, we aimed to determine if Quantitative Light-induced Fluorescence (QLF) parameters--area (A [mm(2)]), fluorescence loss (F [%]), and Q [% × mm(2)]--obtained by image analyses can predict lesion progression. We secured consent from 565 children (from 5-13 years old) and their parents/guardians and examined them at baseline and regular intervals over 48 months according to the International Caries Detection Assessment System (ICDAS), yearly radiographs, and QLF. QLF images from surfaces with ICDAS 0/1/2/3/4 at baseline that progressed (N = 2,191) to cavitation (ICDAS 5/6) or fillings and surfaces that did not progress to cavitation/fillings (N = 4,141) were analyzed independently for A, F, and Q. Linear mixed-effects models were used to compare means and slopes (changes over time) between surfaces that progressed and those that did not. QLF A, F, and Q increased at a faster rate for surfaces that progressed than for surfaces that did not progress (p = .0001), regardless of type of surface or baseline ICDAS score. AUC for ICDAS ranged from 0.65 to 0.80, but adding QLF information improved AUC (0.82-0.87, p <.0005). We concluded that faster changes in QLF variables can indicate lesion progression toward cavitation and be more clinically relevant than actual QLF values.

Original languageEnglish (US)
JournalJournal of Dental Research
Volume92
Issue number7 Suppl
StatePublished - Jul 2013

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Observational Studies
Fluorescence
Light
Area Under Curve
Risk Management
Parents

ASJC Scopus subject areas

  • Dentistry(all)

Cite this

Ferreira Zandoná, A., Ando, M., Gomez, G. F., Garcia-Corretjer, M., Eckert, G. J., Santiago, E., ... Zero, D. (2013). Longitudinal analyses of early lesions by fluorescence: an observational study. Journal of Dental Research, 92(7 Suppl).

Longitudinal analyses of early lesions by fluorescence : an observational study. / Ferreira Zandoná, A.; Ando, Masatoshi; Gomez, G. F.; Garcia-Corretjer, M.; Eckert, G. J.; Santiago, E.; Katz, Barry; Zero, Domenick.

In: Journal of Dental Research, Vol. 92, No. 7 Suppl, 07.2013.

Research output: Contribution to journalArticle

Ferreira Zandoná, A, Ando, M, Gomez, GF, Garcia-Corretjer, M, Eckert, GJ, Santiago, E, Katz, B & Zero, D 2013, 'Longitudinal analyses of early lesions by fluorescence: an observational study.', Journal of Dental Research, vol. 92, no. 7 Suppl.
Ferreira Zandoná A, Ando M, Gomez GF, Garcia-Corretjer M, Eckert GJ, Santiago E et al. Longitudinal analyses of early lesions by fluorescence: an observational study. Journal of Dental Research. 2013 Jul;92(7 Suppl).
Ferreira Zandoná, A. ; Ando, Masatoshi ; Gomez, G. F. ; Garcia-Corretjer, M. ; Eckert, G. J. ; Santiago, E. ; Katz, Barry ; Zero, Domenick. / Longitudinal analyses of early lesions by fluorescence : an observational study. In: Journal of Dental Research. 2013 ; Vol. 92, No. 7 Suppl.
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abstract = "Previous caries experience correlates to future caries risk; thus, early identification of lesions has importance for risk assessment and management. In this study, we aimed to determine if Quantitative Light-induced Fluorescence (QLF) parameters--area (A [mm(2)]), fluorescence loss (F [{\%}]), and Q [{\%} × mm(2)]--obtained by image analyses can predict lesion progression. We secured consent from 565 children (from 5-13 years old) and their parents/guardians and examined them at baseline and regular intervals over 48 months according to the International Caries Detection Assessment System (ICDAS), yearly radiographs, and QLF. QLF images from surfaces with ICDAS 0/1/2/3/4 at baseline that progressed (N = 2,191) to cavitation (ICDAS 5/6) or fillings and surfaces that did not progress to cavitation/fillings (N = 4,141) were analyzed independently for A, F, and Q. Linear mixed-effects models were used to compare means and slopes (changes over time) between surfaces that progressed and those that did not. QLF A, F, and Q increased at a faster rate for surfaces that progressed than for surfaces that did not progress (p = .0001), regardless of type of surface or baseline ICDAS score. AUC for ICDAS ranged from 0.65 to 0.80, but adding QLF information improved AUC (0.82-0.87, p <.0005). We concluded that faster changes in QLF variables can indicate lesion progression toward cavitation and be more clinically relevant than actual QLF values.",
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