Longitudinal analysis of the relationship between serum insulin-like growth factor-I and radiographic knee osteoarthritis

Liana Fraenkel, Yuqing Zhang, Stephen B. Trippel, Timothy E. McAlindon, Michael P. LaValley, Ahmed Assif, Kathryn E. Adams, Stephen R. Evans, David T. Felson

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Objective: To examine the relation between serum insulin-like growth factor I (IGF-I) levels and both incident and progressive radiographic knee osteoarthritis (OA) in the Framingham Osteoarthritis Study. Design: Subjects had bilateral weight-bearing, anterior-posterior knee radiographs performed in 1983-1985 and again in 1992-1993. IGF-I levels were measured from blood specimens obtained in 1988-1989 by a competitive binding radio-immunoassay (RIA) after separation with octadecasilyl-silica cartridges of serum IGF-I from binding proteins. Participants without baseline radiographic OA [Kellgren and Lawrence grades (K and L) = 0-1] were classified as having incident disease if they had K and L ≤ 2 grades at follow-up. Progressive OA was defined as an increase in K and L score of ≤ 1 in knees with baseline OA (K and L ≤ 2). All analyses were knee-based and sex-specific. We examined IGF-I tertiles in relation to the risk of incident and progressive radiographic OA separately, adjusting for age, body mass index (BMI), and baseline K and L score, and used generalized estimating equations to adjust for the correlation between fellow knees. Results: Four hundred and forty- one participants had knee radiographs and serum IGF-I levels measured. No associations were found for serum IGF-I levels and incident [women: OR = 0.9 (0.6-1.7), men OR = 1.2 (0.6-2.6)] or progressive [women OR = 0.9 (0.6-1.6), men OR = 0.9 (0.3-3.0)] radiographic knee OA in either sex. Neither did we observe any association between IGF-I and worsening of individual radiographic features of OA (i.e., osteophyte growth and joint space loss). Conclusion: In summary, this longitudinal study did not demonstrate any association of serum IGF-I and incident or progressive radiographic knee OA. Further studies are needed to clarify the role of IGF-I in OA.

Original languageEnglish (US)
Pages (from-to)362-367
Number of pages6
JournalOsteoarthritis and Cartilage
Volume6
Issue number5
DOIs
StatePublished - Sep 1998

Keywords

  • IGF-I
  • Knee
  • Osteoarthritis
  • Radiograph

ASJC Scopus subject areas

  • Rheumatology
  • Biomedical Engineering
  • Orthopedics and Sports Medicine

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    Fraenkel, L., Zhang, Y., Trippel, S. B., McAlindon, T. E., LaValley, M. P., Assif, A., Adams, K. E., Evans, S. R., & Felson, D. T. (1998). Longitudinal analysis of the relationship between serum insulin-like growth factor-I and radiographic knee osteoarthritis. Osteoarthritis and Cartilage, 6(5), 362-367. https://doi.org/10.1053/joca.1998.0135