Longitudinal functional models with structured penalties

Madan G. Kundu, Jaroslaw Harezlak, Timothy W. Randolph

Research output: Contribution to journalArticle

3 Scopus citations


This article addresses estimation in regression models for longitudinally collected functional covariates (time-varying predictor curves) with a longitudinal scalar outcome. The framework consists of estimating a time-varying coefficient function that is modelled as a linear combination of time-invariant functions with time-varying coefficients. The model uses extrinsic information to inform the structure of the penalty, while the estimation procedure exploits the equivalence between penalized least squares estimation and a linear mixed model representation. The process is empirically evaluated with several simulations and it is applied to analyze the neurocognitive impairment of human immunodeficiency virus (HIV) patients and its association with longitudinally-collected magnetic resonance spectroscopy (MRS) curves.

Original languageEnglish (US)
Pages (from-to)114-139
Number of pages26
JournalStatistical Modelling
Issue number2
StatePublished - 2016


  • LongPEER estimate
  • Longitudinal data
  • functional data analysis
  • generalized singular value decomposition
  • structured penalty

ASJC Scopus subject areas

  • Statistics and Probability
  • Statistics, Probability and Uncertainty

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