Longitudinal maternal vitamin D status during pregnancy is associated with neonatal anthropometric measures

Ellen C. Francis, Stefanie N. Hinkle, Yiqing Song, Shristi Rawal, Sarah R. Donnelly, Yeyi Zhu, Liwei Chen, Cuilin Zhang

Research output: Contribution to journalArticle

Abstract

Findings on maternal 25-hydroxyvitamin D (25[OH]D) and neonatal anthropometry are inconsistent, and may at least be partly due to variations in gestational week (GW) of 25(OH)D measurement and the lack of longitudinal 25(OH)D measurements across gestation. The aim of the current study was to examine the associations of longitudinal measures of maternal 25(OH)D and neonatal anthropometry at birth. This study included 321 mother–offspring pairs enrolled in the Eunice Kennedy Shriver National Institute of Child Health and Human Development Fetal Growth Studies–Singletons. This study was a prospective cohort design without supplementation and without data on dietary supplementation. Nevertheless, measurement of plasma 25(OH)D reflects vitamin D from different sources, including supplementation. Maternal concentrations of total 25(OH)D were measured at 10–14, 15–26, 23–31, and 33–39 GW and categorized as <50 nmol/L, 50–75 nmol/L, and >75 nmol/L. Generalized linear models were used to examine associations of 25(OH)D at each time-point with neonate birthweight z-score, length, and sum of skinfolds at birth. At 10–14 GW, 16.8% and 49.2% of women had 25(OH)D <50 nmol/L and between 50–75 nmol/L, respectively. The association of maternal 25(OH)D with neonatal anthropometry differed by GW and women’s prepregnancy BMI (normal (<25.0 kg/m2), overweight/obese (25.0–44.9 kg/m2)). All analyses were stratified by prepregnancy BMI status. Among women with an overweight/obese BMI, 25(OH)D <50 nmol/L at 10–14 GW was associated with lower birthweight z-score (0.56; 95% CI: −0.99, −0.13) and length (−1.56 cm; 95% CI: −3.07, −0.06), and at 23–31 GW was associated with shorter length (−2.77 cm; 95% CI: −13.38, −4.98) and lower sum of skinfolds (−9.18 mm; 95% CI: −13.38, −4.98). Among women with a normal BMI, 25(OH)D <50 nmol/L at 10–14 GW was associated with lower sum of skinfolds (−2.64 mm; 95% CI: −5.03, −0.24), at 23–31 GW was associated with larger birthweight z-scores (0.64; 95% CI: 0.03, 1.25), and at 33-39 GW with both higher birthweight z-score (1.22; 95% CI: 0.71, 1.73) and longer length (1.94 cm; 95% CI: 0.37, 3.52). Maternal 25(OH)D status during pregnancy was associated with neonatal anthropometric measures, and the associations were specific to GW of 25(OH)D measurement and prepregnancy BMI.

Original languageEnglish (US)
Article number1631
JournalNutrients
Volume10
Issue number11
DOIs
StatePublished - Nov 2 2018

Fingerprint

vitamin D
Vitamin D
anthropometric measurements
Anthropometry
Mothers
pregnancy
birth weight
Pregnancy
National Institute of Child Health and Human Development (U.S.)
human development
Parturition
low birth weight
fetal development
dietary supplements
Dietary Supplements
Fetal Development
neonates
linear models
Linear Models
Newborn Infant

Keywords

  • Fetal growth
  • Infant
  • Maternal
  • Neonate anthropometry
  • Vitamin D

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics

Cite this

Francis, E. C., Hinkle, S. N., Song, Y., Rawal, S., Donnelly, S. R., Zhu, Y., ... Zhang, C. (2018). Longitudinal maternal vitamin D status during pregnancy is associated with neonatal anthropometric measures. Nutrients, 10(11), [1631]. https://doi.org/10.3390/nu10111631

Longitudinal maternal vitamin D status during pregnancy is associated with neonatal anthropometric measures. / Francis, Ellen C.; Hinkle, Stefanie N.; Song, Yiqing; Rawal, Shristi; Donnelly, Sarah R.; Zhu, Yeyi; Chen, Liwei; Zhang, Cuilin.

In: Nutrients, Vol. 10, No. 11, 1631, 02.11.2018.

Research output: Contribution to journalArticle

Francis, EC, Hinkle, SN, Song, Y, Rawal, S, Donnelly, SR, Zhu, Y, Chen, L & Zhang, C 2018, 'Longitudinal maternal vitamin D status during pregnancy is associated with neonatal anthropometric measures', Nutrients, vol. 10, no. 11, 1631. https://doi.org/10.3390/nu10111631
Francis, Ellen C. ; Hinkle, Stefanie N. ; Song, Yiqing ; Rawal, Shristi ; Donnelly, Sarah R. ; Zhu, Yeyi ; Chen, Liwei ; Zhang, Cuilin. / Longitudinal maternal vitamin D status during pregnancy is associated with neonatal anthropometric measures. In: Nutrients. 2018 ; Vol. 10, No. 11.
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N2 - Findings on maternal 25-hydroxyvitamin D (25[OH]D) and neonatal anthropometry are inconsistent, and may at least be partly due to variations in gestational week (GW) of 25(OH)D measurement and the lack of longitudinal 25(OH)D measurements across gestation. The aim of the current study was to examine the associations of longitudinal measures of maternal 25(OH)D and neonatal anthropometry at birth. This study included 321 mother–offspring pairs enrolled in the Eunice Kennedy Shriver National Institute of Child Health and Human Development Fetal Growth Studies–Singletons. This study was a prospective cohort design without supplementation and without data on dietary supplementation. Nevertheless, measurement of plasma 25(OH)D reflects vitamin D from different sources, including supplementation. Maternal concentrations of total 25(OH)D were measured at 10–14, 15–26, 23–31, and 33–39 GW and categorized as <50 nmol/L, 50–75 nmol/L, and >75 nmol/L. Generalized linear models were used to examine associations of 25(OH)D at each time-point with neonate birthweight z-score, length, and sum of skinfolds at birth. At 10–14 GW, 16.8% and 49.2% of women had 25(OH)D <50 nmol/L and between 50–75 nmol/L, respectively. The association of maternal 25(OH)D with neonatal anthropometry differed by GW and women’s prepregnancy BMI (normal (<25.0 kg/m2), overweight/obese (25.0–44.9 kg/m2)). All analyses were stratified by prepregnancy BMI status. Among women with an overweight/obese BMI, 25(OH)D <50 nmol/L at 10–14 GW was associated with lower birthweight z-score (0.56; 95% CI: −0.99, −0.13) and length (−1.56 cm; 95% CI: −3.07, −0.06), and at 23–31 GW was associated with shorter length (−2.77 cm; 95% CI: −13.38, −4.98) and lower sum of skinfolds (−9.18 mm; 95% CI: −13.38, −4.98). Among women with a normal BMI, 25(OH)D <50 nmol/L at 10–14 GW was associated with lower sum of skinfolds (−2.64 mm; 95% CI: −5.03, −0.24), at 23–31 GW was associated with larger birthweight z-scores (0.64; 95% CI: 0.03, 1.25), and at 33-39 GW with both higher birthweight z-score (1.22; 95% CI: 0.71, 1.73) and longer length (1.94 cm; 95% CI: 0.37, 3.52). Maternal 25(OH)D status during pregnancy was associated with neonatal anthropometric measures, and the associations were specific to GW of 25(OH)D measurement and prepregnancy BMI.

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