Loss of BRCA1 expression in sporadic male breast carcinoma

Xiaoping Sun, Yun Gong, M. Sambasiva Rao, Sunil Badve

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

BRCA1 protein is normally expressed in the nuclei of breast epithelial cells and functions as a negative regulator of the cell cycle. Mutations of BRCA1 gene have been associated with familial breast carcinomas. Although somatic mutations have not been demonstrated in sporadic breast carcinomas, loss of nuclear expression of BRCA1 protein has been correlated with high-grade, infiltrating breast carcinomas in females. We have investigated the expression of BRCA1 protein in a series of 26 infiltrating carcinomas of male breast and correlated the results with a variety of clinicopathological parameters. Immunohistochemical analysis demonstrated decreased expression of BRCA1 in all carcinomas compared to normal breast epithelium. The median survival was 8 years in patients with minimal loss of BRCA1 expression while it was 1.5 years in patients with marked loss of this protein. Marked loss of BRCA1 protein was also associated with increased cell proliferation. These results suggest that BRCA1 plays a similar role in both male and female breast carcinoma and loss of this protein is associated with poor prognosis.

Original languageEnglish (US)
Pages (from-to)1-7
Number of pages7
JournalBreast Cancer Research and Treatment
Volume71
Issue number1
DOIs
StatePublished - 2002
Externally publishedYes

Fingerprint

BRCA1 Protein
Male Breast Neoplasms
Breast Neoplasms
Breast
BRCA1 Gene
Mutation
Cell Cycle
Proteins
Epithelium
Epithelial Cells
Cell Proliferation
Carcinoma
Survival

Keywords

  • BRCA1
  • Immunohistochemistry
  • Male breast carcinoma
  • Tumor suppressor gene

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Loss of BRCA1 expression in sporadic male breast carcinoma. / Sun, Xiaoping; Gong, Yun; Rao, M. Sambasiva; Badve, Sunil.

In: Breast Cancer Research and Treatment, Vol. 71, No. 1, 2002, p. 1-7.

Research output: Contribution to journalArticle

Sun, Xiaoping ; Gong, Yun ; Rao, M. Sambasiva ; Badve, Sunil. / Loss of BRCA1 expression in sporadic male breast carcinoma. In: Breast Cancer Research and Treatment. 2002 ; Vol. 71, No. 1. pp. 1-7.
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