Loss of chromosome 9p is an independent prognostic factor in patients with clear cell renal cell carcinoma

Matteo Brunelli, Albino Eccher, Stefano Gobbo, Vincenzo Ficarra, Giacomo Novara, Paolo Cossu-Rocca, Franco Bonetti, Fabio Menestrina, Liang Cheng, John N. Eble, Guido Martignoni

Research output: Contribution to journalArticlepeer-review

71 Scopus citations

Abstract

Loss of chromosome 9p has been implicated in the progression of renal cell carcinoma. We evaluated the clinical utility of fluorescence in situ hybridization analysis of loss of chromosome 9p in 73 patients with clear cell renal cell carcinomas with varied stage, size, grade, necrosis (SSIGN) scores. Loss of chromosome 9p was observed in 13 tumors (18%). The 5-year cancer-specific survival of patients without loss of chromosome 9p was 88% and was 43% in those with loss of chromosome 9p (P<0.001). Local extension of the primary tumor according to the 2002 TNM staging system, lymph node involvement, the presence of distant metastases, and the SSIGN score were the other variables that predicted cancer-specific survival in univariate analysis. Loss of chromosome 9p was an independent prognostic factor in multivariate analysis. Our data indicate that the detection of chromosome 9p loss by fluorescence in situ hybridization analysis of clear cell renal cell carcinoma adds prognostic information beyond the pathological factors included in the current predictive models for renal cell carcinoma, such as SSIGN score.

Original languageEnglish (US)
Pages (from-to)1-6
Number of pages6
JournalModern Pathology
Volume21
Issue number1
DOIs
StatePublished - Jan 2008

Keywords

  • Chromosome 9p loss
  • Clear cell renal cell carcinoma
  • Fluorescence in situ hybridization
  • Interphase cytogenetics
  • Prognosis
  • SSIGN score

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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