Loss of heterozygosity on the short arm of chromosomes 1 and 3 in sporadic pheochromocytoma and extra-adrenal paraganglioma

M. P. Vargas, Z. Zhuang, C. Wang, Alexander Vortmeyer, W. M. Lineman, M. J. Merino

Research output: Contribution to journalArticle

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Abstract

Pheochromocytomas and extra-adrenal paragangliomas are tumors of the paraganglia with similar histological characteristics. We examined 12 sporadic pheochromocytomas and 5 extra-adrenal paragangliomas for loss of heterozygosity (LOH) in chromosomes 1p and 3p using a microdissection technique. Chromosomes 1p34-36, 3p21 and the von Hippel-Lindau (VHL) gene locus (3p25) were analyzed. LOH of a selected region on chromosome 1p was detected in 5 of 11 (45%) informative pheochromocytoma cases and in 0 of 5 (0%) informative extra-adrenal paraganglioma cases. LOH of the chromosome 3p25 VHL gene locus was detected in 5 of 9 (45%) informative pheochromocytoma cases and in 0 of 3 (0%) informative extra-adrenal paraganglioma cases. LOH of 3p21 was detected in 2 of 4 (50%) informative extra-adrenal paraganglioma cases. The allelic deletions in chromosomes 1p and 3p appear to be separate events. In conclusion, significant deletions were found at 1p34-36 and 3p25 in sporadic pheochromocytomas but not in extra-adrenal paragangliomas. These findings suggest (1) that multiple genetic factors may be involved in pheochromocytoma tumorigenesis, and (2) extra-adrenal paragangliomas may have a different genetic mechanism of tumorigenesis compared with pheochromocytomas.

Original languageEnglish (US)
Pages (from-to)411-415
Number of pages5
JournalHuman Pathology
Volume28
Issue number4
DOIs
StatePublished - Jan 1 1997
Externally publishedYes

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Extra-Adrenal Paraganglioma
Chromosomes, Human, Pair 3
Loss of Heterozygosity
Chromosomes, Human, Pair 1
Pheochromocytoma
Chromosomes
Carcinogenesis
Chromosome Deletion
Microdissection
Genes

Keywords

  • extra-adrenal paraganglioma
  • loss of heterozygosity
  • microdissection
  • pheochromocytoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Loss of heterozygosity on the short arm of chromosomes 1 and 3 in sporadic pheochromocytoma and extra-adrenal paraganglioma. / Vargas, M. P.; Zhuang, Z.; Wang, C.; Vortmeyer, Alexander; Lineman, W. M.; Merino, M. J.

In: Human Pathology, Vol. 28, No. 4, 01.01.1997, p. 411-415.

Research output: Contribution to journalArticle

Vargas, M. P. ; Zhuang, Z. ; Wang, C. ; Vortmeyer, Alexander ; Lineman, W. M. ; Merino, M. J. / Loss of heterozygosity on the short arm of chromosomes 1 and 3 in sporadic pheochromocytoma and extra-adrenal paraganglioma. In: Human Pathology. 1997 ; Vol. 28, No. 4. pp. 411-415.
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