Loss of sexual differentiation of rat hepatocytes in short-term culture.

J. E. Roepke, D. W. Crabb

Research output: Contribution to journalArticle

1 Scopus citations


We investigated the maintenance of alcohol dehydrogenase (ADH) and estrogen receptors in primary cultures of rat hepatocytes. Female hepatocytes partially lose ADH activity and completely lose estrogen receptors during 4 days in culture. Growth hormone, which induces both the enzyme and receptor in vivo, did not induce either in vitro.

Original languageEnglish (US)
Pages (from-to)263-264
Number of pages2
JournalAlcohol and alcoholism (Oxford, Oxfordshire). Supplement.
StatePublished - 1987


ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Toxicology
  • Psychiatry and Mental health

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