Loss of sexual differentiation of rat hepatocytes in short-term culture.

J. E. Roepke, D. W. Crabb

Research output: Contribution to journalArticle

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Abstract

We investigated the maintenance of alcohol dehydrogenase (ADH) and estrogen receptors in primary cultures of rat hepatocytes. Female hepatocytes partially lose ADH activity and completely lose estrogen receptors during 4 days in culture. Growth hormone, which induces both the enzyme and receptor in vivo, did not induce either in vitro.

Original languageEnglish (US)
Pages (from-to)263-264
Number of pages2
JournalAlcohol and alcoholism (Oxford, Oxfordshire). Supplement.
Volume1
StatePublished - 1987

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ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Toxicology
  • Psychiatry and Mental health

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