Lost in translation: Endoplasmic reticulum stress and the decline of β-cell health in diabetes mellitus

Research output: Contribution to journalReview article

28 Scopus citations

Abstract

Emerging data illustrate a pivotal role for activation of β-cell endoplasmic reticulum (ER) stress pathways in diabetes pathophysiology. The purpose of this review is to appraise the evidence for β-cell ER stress in human type 1 and 2 diabetes, review the molecular signalling pathways involved in the unfolded protein response and ER stress signalling, and to provide data from polyribosome profiling to illustrate the impact of ER stress on the mRNA translation response. Finally, we will discuss existing and novel therapeutic strategies that target β-cell ER stress and discuss their use in rodent and human type 1 and 2 diabetes.

Original languageEnglish (US)
Pages (from-to)159-169
Number of pages11
JournalDiabetes, Obesity and Metabolism
Volume15
Issue numberS3
DOIs
StatePublished - Sep 2013

Keywords

  • Diabetes
  • ER stress
  • Islet
  • MRNA translation
  • Polyribosome

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

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