Lost to follow-up among pregnant women in a multi-site community based maternal and newborn health registry

A prospective study

Irene Marete, Constance Tenge, Carolyne Chemweno, Sherri Bucher, Omrana Pasha, Umesh Y. Ramadurg, Shivanand C. Mastiholi, Melody Chiwila, Archana Patel, Fernando Althabe, Ana Garces, Janet L. Moore, Edward A. Liechty, Richard J. Derman, Patricia L. Hibberd, K. Michael Hambidge, Robert L. Goldenberg, Waldemar A. Carlo, Marion Koso-Thomas, Elizabeth M. McClure & 1 others Fabian Esamai

Research output: Contribution to journalReview article

3 Citations (Scopus)

Abstract

Background: It is important when conducting epidemiologic studies to closely monitor lost to follow up (LTFU) rates. A high LTFU rate may lead to incomplete study results which in turn can introduce bias to the trial or study, threatening the validity of the findings. There is scarce information on LTFU in prospective community-based perinatal epidemiological studies. This paper reports the rates of LTFU, describes socio-demographic characteristics, and pregnancy/delivery outcomes of mothers LTFU in a large community-based pregnancy registry study. Methods: Data were from a prospective, population-based observational study of the Global Network for Women's and Children's Health Research Maternal Newborn Health Registry (MNHR). This is a multi-centre, international study in which pregnant women were enrolled in mid-pregnancy, followed through parturition and 42 days post-delivery. Risk for LTFU was calculated within a 95%CI. Results: A total of 282,626 subjects were enrolled in this study, of which 4,893 were lost to follow-up. Overall, there was a 1.7% LTFU to follow up rate. Factors associated with a higher LTFU included mothers who did not know their last menstrual period (RR 2.2, 95% CI 1.1, 4.4), maternal age of < 20 years (RR 1.2, 95% CI 1.1, 1.3), women with no formal education (RR 1.2, 95% CI 1.1, 1.4), and attending a government clinic for antenatal care (RR 2.0, 95% CI 1.4, 2.8). Post-natal factors associated with a higher LTFU rate included a newborn with feeding problems (RR 1.6, 94% CI 1.2, 2.2). Conclusions: The LTFU rate in this community-based registry was low (1.7%). Maternal age, maternal level of education, pregnancy status at enrollment and using a government facility for ANC are factors associated with being LTFU. Strategies to ensure representation and high retention in community studies are important to informing progress toward public health goals.

Original languageEnglish (US)
Article numberS4
JournalReproductive Health
Volume12
Issue number2
DOIs
StatePublished - Jun 8 2015

Fingerprint

Lost to Follow-Up
Registries
Pregnant Women
Prospective Studies
Maternal Age
Mothers
Pregnancy
Infant Health
Maternal Health
Epidemiologic Studies
Education
Prenatal Care
Women's Health
Pregnancy Outcome
Observational Studies
Public Health
Demography
Parturition
Newborn Infant

Keywords

  • Community based registry
  • Lost to follow up rate
  • Maternal and newborn registry
  • Maternal socio demographic characteristics
  • Pregnancy outcomes

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Reproductive Medicine

Cite this

Lost to follow-up among pregnant women in a multi-site community based maternal and newborn health registry : A prospective study. / Marete, Irene; Tenge, Constance; Chemweno, Carolyne; Bucher, Sherri; Pasha, Omrana; Ramadurg, Umesh Y.; Mastiholi, Shivanand C.; Chiwila, Melody; Patel, Archana; Althabe, Fernando; Garces, Ana; Moore, Janet L.; Liechty, Edward A.; Derman, Richard J.; Hibberd, Patricia L.; Hambidge, K. Michael; Goldenberg, Robert L.; Carlo, Waldemar A.; Koso-Thomas, Marion; McClure, Elizabeth M.; Esamai, Fabian.

In: Reproductive Health, Vol. 12, No. 2, S4, 08.06.2015.

Research output: Contribution to journalReview article

Marete, I, Tenge, C, Chemweno, C, Bucher, S, Pasha, O, Ramadurg, UY, Mastiholi, SC, Chiwila, M, Patel, A, Althabe, F, Garces, A, Moore, JL, Liechty, EA, Derman, RJ, Hibberd, PL, Hambidge, KM, Goldenberg, RL, Carlo, WA, Koso-Thomas, M, McClure, EM & Esamai, F 2015, 'Lost to follow-up among pregnant women in a multi-site community based maternal and newborn health registry: A prospective study', Reproductive Health, vol. 12, no. 2, S4. https://doi.org/10.1186/1742-4755-12-S2-S4
Marete, Irene ; Tenge, Constance ; Chemweno, Carolyne ; Bucher, Sherri ; Pasha, Omrana ; Ramadurg, Umesh Y. ; Mastiholi, Shivanand C. ; Chiwila, Melody ; Patel, Archana ; Althabe, Fernando ; Garces, Ana ; Moore, Janet L. ; Liechty, Edward A. ; Derman, Richard J. ; Hibberd, Patricia L. ; Hambidge, K. Michael ; Goldenberg, Robert L. ; Carlo, Waldemar A. ; Koso-Thomas, Marion ; McClure, Elizabeth M. ; Esamai, Fabian. / Lost to follow-up among pregnant women in a multi-site community based maternal and newborn health registry : A prospective study. In: Reproductive Health. 2015 ; Vol. 12, No. 2.
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title = "Lost to follow-up among pregnant women in a multi-site community based maternal and newborn health registry: A prospective study",
abstract = "Background: It is important when conducting epidemiologic studies to closely monitor lost to follow up (LTFU) rates. A high LTFU rate may lead to incomplete study results which in turn can introduce bias to the trial or study, threatening the validity of the findings. There is scarce information on LTFU in prospective community-based perinatal epidemiological studies. This paper reports the rates of LTFU, describes socio-demographic characteristics, and pregnancy/delivery outcomes of mothers LTFU in a large community-based pregnancy registry study. Methods: Data were from a prospective, population-based observational study of the Global Network for Women's and Children's Health Research Maternal Newborn Health Registry (MNHR). This is a multi-centre, international study in which pregnant women were enrolled in mid-pregnancy, followed through parturition and 42 days post-delivery. Risk for LTFU was calculated within a 95{\%}CI. Results: A total of 282,626 subjects were enrolled in this study, of which 4,893 were lost to follow-up. Overall, there was a 1.7{\%} LTFU to follow up rate. Factors associated with a higher LTFU included mothers who did not know their last menstrual period (RR 2.2, 95{\%} CI 1.1, 4.4), maternal age of < 20 years (RR 1.2, 95{\%} CI 1.1, 1.3), women with no formal education (RR 1.2, 95{\%} CI 1.1, 1.4), and attending a government clinic for antenatal care (RR 2.0, 95{\%} CI 1.4, 2.8). Post-natal factors associated with a higher LTFU rate included a newborn with feeding problems (RR 1.6, 94{\%} CI 1.2, 2.2). Conclusions: The LTFU rate in this community-based registry was low (1.7{\%}). Maternal age, maternal level of education, pregnancy status at enrollment and using a government facility for ANC are factors associated with being LTFU. Strategies to ensure representation and high retention in community studies are important to informing progress toward public health goals.",
keywords = "Community based registry, Lost to follow up rate, Maternal and newborn registry, Maternal socio demographic characteristics, Pregnancy outcomes",
author = "Irene Marete and Constance Tenge and Carolyne Chemweno and Sherri Bucher and Omrana Pasha and Ramadurg, {Umesh Y.} and Mastiholi, {Shivanand C.} and Melody Chiwila and Archana Patel and Fernando Althabe and Ana Garces and Moore, {Janet L.} and Liechty, {Edward A.} and Derman, {Richard J.} and Hibberd, {Patricia L.} and Hambidge, {K. Michael} and Goldenberg, {Robert L.} and Carlo, {Waldemar A.} and Marion Koso-Thomas and McClure, {Elizabeth M.} and Fabian Esamai",
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language = "English (US)",
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TY - JOUR

T1 - Lost to follow-up among pregnant women in a multi-site community based maternal and newborn health registry

T2 - A prospective study

AU - Marete, Irene

AU - Tenge, Constance

AU - Chemweno, Carolyne

AU - Bucher, Sherri

AU - Pasha, Omrana

AU - Ramadurg, Umesh Y.

AU - Mastiholi, Shivanand C.

AU - Chiwila, Melody

AU - Patel, Archana

AU - Althabe, Fernando

AU - Garces, Ana

AU - Moore, Janet L.

AU - Liechty, Edward A.

AU - Derman, Richard J.

AU - Hibberd, Patricia L.

AU - Hambidge, K. Michael

AU - Goldenberg, Robert L.

AU - Carlo, Waldemar A.

AU - Koso-Thomas, Marion

AU - McClure, Elizabeth M.

AU - Esamai, Fabian

PY - 2015/6/8

Y1 - 2015/6/8

N2 - Background: It is important when conducting epidemiologic studies to closely monitor lost to follow up (LTFU) rates. A high LTFU rate may lead to incomplete study results which in turn can introduce bias to the trial or study, threatening the validity of the findings. There is scarce information on LTFU in prospective community-based perinatal epidemiological studies. This paper reports the rates of LTFU, describes socio-demographic characteristics, and pregnancy/delivery outcomes of mothers LTFU in a large community-based pregnancy registry study. Methods: Data were from a prospective, population-based observational study of the Global Network for Women's and Children's Health Research Maternal Newborn Health Registry (MNHR). This is a multi-centre, international study in which pregnant women were enrolled in mid-pregnancy, followed through parturition and 42 days post-delivery. Risk for LTFU was calculated within a 95%CI. Results: A total of 282,626 subjects were enrolled in this study, of which 4,893 were lost to follow-up. Overall, there was a 1.7% LTFU to follow up rate. Factors associated with a higher LTFU included mothers who did not know their last menstrual period (RR 2.2, 95% CI 1.1, 4.4), maternal age of < 20 years (RR 1.2, 95% CI 1.1, 1.3), women with no formal education (RR 1.2, 95% CI 1.1, 1.4), and attending a government clinic for antenatal care (RR 2.0, 95% CI 1.4, 2.8). Post-natal factors associated with a higher LTFU rate included a newborn with feeding problems (RR 1.6, 94% CI 1.2, 2.2). Conclusions: The LTFU rate in this community-based registry was low (1.7%). Maternal age, maternal level of education, pregnancy status at enrollment and using a government facility for ANC are factors associated with being LTFU. Strategies to ensure representation and high retention in community studies are important to informing progress toward public health goals.

AB - Background: It is important when conducting epidemiologic studies to closely monitor lost to follow up (LTFU) rates. A high LTFU rate may lead to incomplete study results which in turn can introduce bias to the trial or study, threatening the validity of the findings. There is scarce information on LTFU in prospective community-based perinatal epidemiological studies. This paper reports the rates of LTFU, describes socio-demographic characteristics, and pregnancy/delivery outcomes of mothers LTFU in a large community-based pregnancy registry study. Methods: Data were from a prospective, population-based observational study of the Global Network for Women's and Children's Health Research Maternal Newborn Health Registry (MNHR). This is a multi-centre, international study in which pregnant women were enrolled in mid-pregnancy, followed through parturition and 42 days post-delivery. Risk for LTFU was calculated within a 95%CI. Results: A total of 282,626 subjects were enrolled in this study, of which 4,893 were lost to follow-up. Overall, there was a 1.7% LTFU to follow up rate. Factors associated with a higher LTFU included mothers who did not know their last menstrual period (RR 2.2, 95% CI 1.1, 4.4), maternal age of < 20 years (RR 1.2, 95% CI 1.1, 1.3), women with no formal education (RR 1.2, 95% CI 1.1, 1.4), and attending a government clinic for antenatal care (RR 2.0, 95% CI 1.4, 2.8). Post-natal factors associated with a higher LTFU rate included a newborn with feeding problems (RR 1.6, 94% CI 1.2, 2.2). Conclusions: The LTFU rate in this community-based registry was low (1.7%). Maternal age, maternal level of education, pregnancy status at enrollment and using a government facility for ANC are factors associated with being LTFU. Strategies to ensure representation and high retention in community studies are important to informing progress toward public health goals.

KW - Community based registry

KW - Lost to follow up rate

KW - Maternal and newborn registry

KW - Maternal socio demographic characteristics

KW - Pregnancy outcomes

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U2 - 10.1186/1742-4755-12-S2-S4

DO - 10.1186/1742-4755-12-S2-S4

M3 - Review article

VL - 12

JO - Reproductive Health

JF - Reproductive Health

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