Low and High Birth Weights Are Risk Factors for Nonalcoholic Fatty Liver Disease in Children

Kimberly P. Newton, Haruna S. Feldman, Christina D. Chambers, Laura Wilson, Cynthia Behling, Jeanne M. Clark, Jean Molleston, Naga Chalasani, Arun J. Sanyal, Mark H. Fishbein, Joel E. Lavine, Girish Subbarao

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Objectives: To examine the distribution of birth weight in children with nonalcoholic fatty liver disease (NAFLD) compared with the general US population, and to investigate the relationship between birth weight and severity of NAFLD. Study design: A multicenter, cross-sectional study of children with biopsy-proven NAFLD enrolled in the Nonalcoholic Steatohepatitis Clinical Research Network Database. Birth weight was categorized as low birth weight (LBW), normal birth weight (NBW), or high birth weight (HBW) and compared with the birth weight distribution in the general US population. The severity of liver histology was assessed by birth weight category. Results: Children with NAFLD (n = 538) had overrepresentation of both LBW and HBW compared with the general US population (LBW, 9.3%; NBW, 75.8%; HBW, 14.9% vs LBW, 6.1%; NBW, 83.5%; HBW 10.5%; P < .0001). Children with HBW had significantly greater odds of having more severe steatosis (OR, 1.82, 95% CI. 1.15-2.88) and nonalcoholic steatohepatitis (OR, 2.03; 95% CI, 1.21-3.40) compared with children with NBW. In addition, children with NAFLD and LBW had significantly greater odds of having advanced fibrosis (OR, 2.23; 95% CI, 1.08-4.62). Conclusion: Birth weight involves maternal and in utero factors that may have long-lasting consequences. Children with both LBW and HBW may be at increased risk for developing NAFLD. Among children with NAFLD, those with LBW or HBW appear to be at increased risk for more severe disease.

Original languageEnglish (US)
JournalJournal of Pediatrics
DOIs
StateAccepted/In press - Nov 28 2016

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Low Birth Weight Infant
Birth Weight
Non-alcoholic Fatty Liver Disease
Population

Keywords

  • Birth weight
  • Children
  • Epidemiology
  • Nonalcoholic fatty liver disease
  • Nonalcoholic steatohepatitis
  • Obesity

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Low and High Birth Weights Are Risk Factors for Nonalcoholic Fatty Liver Disease in Children. / Newton, Kimberly P.; Feldman, Haruna S.; Chambers, Christina D.; Wilson, Laura; Behling, Cynthia; Clark, Jeanne M.; Molleston, Jean; Chalasani, Naga; Sanyal, Arun J.; Fishbein, Mark H.; Lavine, Joel E.; Subbarao, Girish.

In: Journal of Pediatrics, 28.11.2016.

Research output: Contribution to journalArticle

Newton, Kimberly P. ; Feldman, Haruna S. ; Chambers, Christina D. ; Wilson, Laura ; Behling, Cynthia ; Clark, Jeanne M. ; Molleston, Jean ; Chalasani, Naga ; Sanyal, Arun J. ; Fishbein, Mark H. ; Lavine, Joel E. ; Subbarao, Girish. / Low and High Birth Weights Are Risk Factors for Nonalcoholic Fatty Liver Disease in Children. In: Journal of Pediatrics. 2016.
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title = "Low and High Birth Weights Are Risk Factors for Nonalcoholic Fatty Liver Disease in Children",
abstract = "Objectives: To examine the distribution of birth weight in children with nonalcoholic fatty liver disease (NAFLD) compared with the general US population, and to investigate the relationship between birth weight and severity of NAFLD. Study design: A multicenter, cross-sectional study of children with biopsy-proven NAFLD enrolled in the Nonalcoholic Steatohepatitis Clinical Research Network Database. Birth weight was categorized as low birth weight (LBW), normal birth weight (NBW), or high birth weight (HBW) and compared with the birth weight distribution in the general US population. The severity of liver histology was assessed by birth weight category. Results: Children with NAFLD (n = 538) had overrepresentation of both LBW and HBW compared with the general US population (LBW, 9.3{\%}; NBW, 75.8{\%}; HBW, 14.9{\%} vs LBW, 6.1{\%}; NBW, 83.5{\%}; HBW 10.5{\%}; P < .0001). Children with HBW had significantly greater odds of having more severe steatosis (OR, 1.82, 95{\%} CI. 1.15-2.88) and nonalcoholic steatohepatitis (OR, 2.03; 95{\%} CI, 1.21-3.40) compared with children with NBW. In addition, children with NAFLD and LBW had significantly greater odds of having advanced fibrosis (OR, 2.23; 95{\%} CI, 1.08-4.62). Conclusion: Birth weight involves maternal and in utero factors that may have long-lasting consequences. Children with both LBW and HBW may be at increased risk for developing NAFLD. Among children with NAFLD, those with LBW or HBW appear to be at increased risk for more severe disease.",
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author = "Newton, {Kimberly P.} and Feldman, {Haruna S.} and Chambers, {Christina D.} and Laura Wilson and Cynthia Behling and Clark, {Jeanne M.} and Jean Molleston and Naga Chalasani and Sanyal, {Arun J.} and Fishbein, {Mark H.} and Lavine, {Joel E.} and Girish Subbarao",
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AU - Newton, Kimberly P.

AU - Feldman, Haruna S.

AU - Chambers, Christina D.

AU - Wilson, Laura

AU - Behling, Cynthia

AU - Clark, Jeanne M.

AU - Molleston, Jean

AU - Chalasani, Naga

AU - Sanyal, Arun J.

AU - Fishbein, Mark H.

AU - Lavine, Joel E.

AU - Subbarao, Girish

PY - 2016/11/28

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N2 - Objectives: To examine the distribution of birth weight in children with nonalcoholic fatty liver disease (NAFLD) compared with the general US population, and to investigate the relationship between birth weight and severity of NAFLD. Study design: A multicenter, cross-sectional study of children with biopsy-proven NAFLD enrolled in the Nonalcoholic Steatohepatitis Clinical Research Network Database. Birth weight was categorized as low birth weight (LBW), normal birth weight (NBW), or high birth weight (HBW) and compared with the birth weight distribution in the general US population. The severity of liver histology was assessed by birth weight category. Results: Children with NAFLD (n = 538) had overrepresentation of both LBW and HBW compared with the general US population (LBW, 9.3%; NBW, 75.8%; HBW, 14.9% vs LBW, 6.1%; NBW, 83.5%; HBW 10.5%; P < .0001). Children with HBW had significantly greater odds of having more severe steatosis (OR, 1.82, 95% CI. 1.15-2.88) and nonalcoholic steatohepatitis (OR, 2.03; 95% CI, 1.21-3.40) compared with children with NBW. In addition, children with NAFLD and LBW had significantly greater odds of having advanced fibrosis (OR, 2.23; 95% CI, 1.08-4.62). Conclusion: Birth weight involves maternal and in utero factors that may have long-lasting consequences. Children with both LBW and HBW may be at increased risk for developing NAFLD. Among children with NAFLD, those with LBW or HBW appear to be at increased risk for more severe disease.

AB - Objectives: To examine the distribution of birth weight in children with nonalcoholic fatty liver disease (NAFLD) compared with the general US population, and to investigate the relationship between birth weight and severity of NAFLD. Study design: A multicenter, cross-sectional study of children with biopsy-proven NAFLD enrolled in the Nonalcoholic Steatohepatitis Clinical Research Network Database. Birth weight was categorized as low birth weight (LBW), normal birth weight (NBW), or high birth weight (HBW) and compared with the birth weight distribution in the general US population. The severity of liver histology was assessed by birth weight category. Results: Children with NAFLD (n = 538) had overrepresentation of both LBW and HBW compared with the general US population (LBW, 9.3%; NBW, 75.8%; HBW, 14.9% vs LBW, 6.1%; NBW, 83.5%; HBW 10.5%; P < .0001). Children with HBW had significantly greater odds of having more severe steatosis (OR, 1.82, 95% CI. 1.15-2.88) and nonalcoholic steatohepatitis (OR, 2.03; 95% CI, 1.21-3.40) compared with children with NBW. In addition, children with NAFLD and LBW had significantly greater odds of having advanced fibrosis (OR, 2.23; 95% CI, 1.08-4.62). Conclusion: Birth weight involves maternal and in utero factors that may have long-lasting consequences. Children with both LBW and HBW may be at increased risk for developing NAFLD. Among children with NAFLD, those with LBW or HBW appear to be at increased risk for more severe disease.

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KW - Children

KW - Epidemiology

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KW - Nonalcoholic steatohepatitis

KW - Obesity

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