Low cell motility induced by hsp27 overexpression decreases osteolytic bone metastases of human breast cancer cells in vivo

Pierre Lemieux, J. Harvey, Theresa Guise, Mark Dallas, Steffi Oesterreich, Juan Juan Yin, Katri Selander, Suzanne Fuqua

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

The mechanisms controlling the formation of osteolytic bone metastases in patients with breast cancer are still poorly understood. To explore the role of motility in the establishment of osteolytic bone metastases, we have used a model of bone metastasis in which MDA-MB-231 breast cancer cells exhibiting low (hsp27-transfectants) and high (control-transfectant) endogenous cell motility were compared. We found that MDA-MB-231 cells exhibiting low cell motility were less capable of establishing osteolytic lesions. The number and the area of the osteolytic lesions in mice inoculated with low motility cells were both significantly smaller. Histomorphometry of bone lesions also demonstrated less tumor area in mice bearing hsp27 transfectants although there was no difference in the osteoclast number per square millimeter of tumor-bone interface. These data suggest that cell motility may be an important mechanism in the metastatic cascade of breast cancer cells to the bone and that controlling cell motility may be a useful target to prevent the establishment of osteolytic bone metastases.

Original languageEnglish (US)
Pages (from-to)1570-1575
Number of pages6
JournalJournal of Bone and Mineral Research
Volume14
Issue number9
DOIs
StatePublished - 1999

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Orthopedics and Sports Medicine

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