Low dopamine-beta-hydroxylase: A biological sequela of abuse and neglect?

Matthew Galvin, Anantha Shekhar, Jay Simon, Barbara Stilwell, Robert Ten Eyck, Gina Laite, George Karwisch, Susanne Blix

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

Twenty-one psychiatrically hospitalized boys were studied while off psychoactive medication to determine if conduct disorder, solitary type, and abuse or neglect experiences correlated with low levels of dopamine-β-hydroxylase (DBH) activity. Preliminary results supported earlier findings that undersocialized types of conduct disorder in boys were correlated with low DBH activity. Possible or definite neglect or abuse before 36 months of age was correlated with low DBH activity. Abuse or neglect was not correlated with low DBH activity when time of occurrence was not specified. Low serum DBH may be a biological sequela of seriously disrupted attachment.

Original languageEnglish (US)
Pages (from-to)1-11
Number of pages11
JournalPsychiatry Research
Volume39
Issue number1
DOIs
StatePublished - Oct 1991

Keywords

  • abuse
  • conduct disorder
  • Dopamine-β-hydroxylase
  • neglect

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Psychology(all)

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    Galvin, M., Shekhar, A., Simon, J., Stilwell, B., Eyck, R. T., Laite, G., Karwisch, G., & Blix, S. (1991). Low dopamine-beta-hydroxylase: A biological sequela of abuse and neglect? Psychiatry Research, 39(1), 1-11. https://doi.org/10.1016/0165-1781(91)90002-7