Low dose total body irradiation: a potent anti-retroviral agent in vivo

Rong Nian Shen, Ned B. Hornback, Li Lu, Li T. Chen, Zacharie Brahmi, Hal E. Broxmeyer

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

Immunosuppression characterizes many human diseases including leukemia and AIDS. Friend virus (FV)-induced murine leukemia is a useful model for studying both malignancy and immunosuppression. In a previous series of experiments, we have demonstrated that untreated FV-infected mice died within 40 days post-infection, whereas infected mice given 150 cGy total body irradiation (TBI) on days 5 and 12 exhibited long-term survival. In this report, we show that no leukemic cells or type C virus particles are found in the spleens of mice treated with TBI. In addition, both NK activity as well as bone marrow cell's proliferative responses to PHA and Con A were fully restored. This treatment produces long term control of FV-induced murine leukemia, and thus might have relevance for the treatment of a number of immunosuppressive diseases including AIDS.

Original languageEnglish (US)
Pages (from-to)165-170
Number of pages6
JournalInternational journal of radiation oncology, biology, physics
Volume16
Issue number1
DOIs
StatePublished - Jan 1989

Keywords

  • AIDS
  • Anti-retroviral agent
  • Friend virus complex (FVC)
  • Immunosuppression
  • Natural Killer (NK) cells
  • Total body irradiation (TBI)

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Radiation

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