Low plasma ApoE levels are associated with smaller hippocampal size in the alzheimer's disease neuroimaging initiative cohort

Edmond Teng, Nicole Chow, Kristy S. Hwang, Paul M. Thompson, Karen H. Gylys, Gregory M. Cole, Clifford R. Jack, Leslie M. Shaw, John Q. Trojanowski, Holly D. Soares, Michael W. Weiner, Liana G. Apostolova

Research output: Contribution to journalArticle

Abstract

Apolipoprotein E (APOE) genotype is the strongest known genetic risk factor for sporadic Alzheimer's disease (AD), but the utility of plasma ApoE levels for assessing the severity of underlying neurodegenerative changes remains uncertain. Here, we examined cross-sectional associations between plasma ApoE levels and volumetric magnetic resonance imaging indices of the hippocampus from 541 participants [57 with normal cognition (NC), 375 with mild cognitive impairment (MCI), and 109 with mild AD] who were enrolled in the Alzheimer's Disease Neuroimaging Initiative. Across the NC and MCI groups, lower plasma ApoE levels were significantly correlated with smaller hippocampal size, as measured by either hippocampal volume or hippocampal radial distance. These associations were driven primarily by findings from carriers of an APOE ε4 allele and are consistent with prior reports that lower plasma ApoE levels correlate with greater global cortical Pittsburgh Compound B retention. In this high-risk group, plasma ApoE levels may represent a peripheral marker of underlying AD neuropathology in nondemented elderly individuals.

Original languageEnglish (US)
Pages (from-to)154-166
Number of pages13
JournalDementia and Geriatric Cognitive Disorders
Volume39
Issue number3-4
DOIs
StatePublished - Apr 18 2015
Externally publishedYes

Fingerprint

Apolipoproteins E
Neuroimaging
Alzheimer Disease
Cognition
Apolipoprotein E4
Hippocampus
Alleles
Genotype
Magnetic Resonance Imaging

Keywords

  • ADNI
  • Alzheimer's disease
  • Apolipoprotein E
  • Biomarkers
  • Hippocampus
  • Magnetic resonance imaging
  • Mild cognitive impairment

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Cognitive Neuroscience
  • Psychiatry and Mental health

Cite this

Low plasma ApoE levels are associated with smaller hippocampal size in the alzheimer's disease neuroimaging initiative cohort. / Teng, Edmond; Chow, Nicole; Hwang, Kristy S.; Thompson, Paul M.; Gylys, Karen H.; Cole, Gregory M.; Jack, Clifford R.; Shaw, Leslie M.; Trojanowski, John Q.; Soares, Holly D.; Weiner, Michael W.; Apostolova, Liana G.

In: Dementia and Geriatric Cognitive Disorders, Vol. 39, No. 3-4, 18.04.2015, p. 154-166.

Research output: Contribution to journalArticle

Teng, E, Chow, N, Hwang, KS, Thompson, PM, Gylys, KH, Cole, GM, Jack, CR, Shaw, LM, Trojanowski, JQ, Soares, HD, Weiner, MW & Apostolova, LG 2015, 'Low plasma ApoE levels are associated with smaller hippocampal size in the alzheimer's disease neuroimaging initiative cohort', Dementia and Geriatric Cognitive Disorders, vol. 39, no. 3-4, pp. 154-166. https://doi.org/10.1159/000368982
Teng, Edmond ; Chow, Nicole ; Hwang, Kristy S. ; Thompson, Paul M. ; Gylys, Karen H. ; Cole, Gregory M. ; Jack, Clifford R. ; Shaw, Leslie M. ; Trojanowski, John Q. ; Soares, Holly D. ; Weiner, Michael W. ; Apostolova, Liana G. / Low plasma ApoE levels are associated with smaller hippocampal size in the alzheimer's disease neuroimaging initiative cohort. In: Dementia and Geriatric Cognitive Disorders. 2015 ; Vol. 39, No. 3-4. pp. 154-166.
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