Low prevalence of antibodies to preerythrocytic but not blood-stage Plasmodium falciparum antigens in an area of unstable malaria transmission compared to prevalence in an area of stable malaria transmission

Gregory S. Noland, Brett Hendel-Paterson, Xinan M. Min, Ann M. Moormann, John M. Vulule, David L. Narum, David E. Lanar, James W. Kazura, Chandy John

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

In areas where levels of transmission of Plasmodium falciparum are high and stable, the age-related acquisition of high-level immunoglobulin G (IgG) antibodies to preerythrocytic circumsporozoite protein (CSP) and liver-stage antigen 1 (LSA-1) has been associated with protection from clinical malaria. In contrast, age-related protection from malaria develops slowly or not at all in residents of epidemic-prone areas with unstable low levels of malaria transmission. We hypothesized that this suboptimal clinical and parasitological immunity may in part be due to reduced antibodies to CSP or LSA-1 and/or vaccine candidate blood-stage antigens. Frequencies and levels of IgG antibodies to CSP, LSA-1, thrombospondin-related adhesive protein (TRAP), apical membrane antigen 1 (AMA-1), erythrocyte binding antigen 175 (EBA-175), and merozoite surface protein 1 (MSP-1) were compared in 243 Kenyans living in a highland area of unstable transmission and 210 residents of a nearby lowland area of stable transmission. Levels of antibodies to CSP, LSA-1, TRAP, and AMA-1 in the oldest age group (>40 years) in the unstable transmission area were lower than or similar to those of children 2 to 6 years old in the stable transmission area. Only 3.3% of individuals in the unstable transmission area had high levels of IgG (>2 arbitrary units) to both CSP and LSA-1, compared to 43.3% of individuals in the stable transmission area. In contrast, antibody levels to and frequencies of MSP-1 and EBA-175 were similar in adults in areas of stable and unstable malaria transmission. Suboptimal immunity to malaria in areas of unstable malaria transmission may relate in part to infrequent high-level antibodies to preerythrocytic antigens and AMA-1.

Original languageEnglish (US)
Pages (from-to)5721-5728
Number of pages8
JournalInfection and Immunity
Volume76
Issue number12
DOIs
StatePublished - Dec 2008
Externally publishedYes

Fingerprint

Plasmodium falciparum
Malaria
Antigens
Antibodies
Merozoite Surface Protein 1
Liver
Thrombospondin 1
Immunoglobulin G
Proteins
Adhesives
Immunity
Membrane Proteins
Erythrocytes
Vaccines
Age Groups

ASJC Scopus subject areas

  • Immunology
  • Microbiology
  • Parasitology
  • Infectious Diseases

Cite this

Low prevalence of antibodies to preerythrocytic but not blood-stage Plasmodium falciparum antigens in an area of unstable malaria transmission compared to prevalence in an area of stable malaria transmission. / Noland, Gregory S.; Hendel-Paterson, Brett; Min, Xinan M.; Moormann, Ann M.; Vulule, John M.; Narum, David L.; Lanar, David E.; Kazura, James W.; John, Chandy.

In: Infection and Immunity, Vol. 76, No. 12, 12.2008, p. 5721-5728.

Research output: Contribution to journalArticle

Noland, Gregory S. ; Hendel-Paterson, Brett ; Min, Xinan M. ; Moormann, Ann M. ; Vulule, John M. ; Narum, David L. ; Lanar, David E. ; Kazura, James W. ; John, Chandy. / Low prevalence of antibodies to preerythrocytic but not blood-stage Plasmodium falciparum antigens in an area of unstable malaria transmission compared to prevalence in an area of stable malaria transmission. In: Infection and Immunity. 2008 ; Vol. 76, No. 12. pp. 5721-5728.
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abstract = "In areas where levels of transmission of Plasmodium falciparum are high and stable, the age-related acquisition of high-level immunoglobulin G (IgG) antibodies to preerythrocytic circumsporozoite protein (CSP) and liver-stage antigen 1 (LSA-1) has been associated with protection from clinical malaria. In contrast, age-related protection from malaria develops slowly or not at all in residents of epidemic-prone areas with unstable low levels of malaria transmission. We hypothesized that this suboptimal clinical and parasitological immunity may in part be due to reduced antibodies to CSP or LSA-1 and/or vaccine candidate blood-stage antigens. Frequencies and levels of IgG antibodies to CSP, LSA-1, thrombospondin-related adhesive protein (TRAP), apical membrane antigen 1 (AMA-1), erythrocyte binding antigen 175 (EBA-175), and merozoite surface protein 1 (MSP-1) were compared in 243 Kenyans living in a highland area of unstable transmission and 210 residents of a nearby lowland area of stable transmission. Levels of antibodies to CSP, LSA-1, TRAP, and AMA-1 in the oldest age group (>40 years) in the unstable transmission area were lower than or similar to those of children 2 to 6 years old in the stable transmission area. Only 3.3{\%} of individuals in the unstable transmission area had high levels of IgG (>2 arbitrary units) to both CSP and LSA-1, compared to 43.3{\%} of individuals in the stable transmission area. In contrast, antibody levels to and frequencies of MSP-1 and EBA-175 were similar in adults in areas of stable and unstable malaria transmission. Suboptimal immunity to malaria in areas of unstable malaria transmission may relate in part to infrequent high-level antibodies to preerythrocytic antigens and AMA-1.",
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T1 - Low prevalence of antibodies to preerythrocytic but not blood-stage Plasmodium falciparum antigens in an area of unstable malaria transmission compared to prevalence in an area of stable malaria transmission

AU - Noland, Gregory S.

AU - Hendel-Paterson, Brett

AU - Min, Xinan M.

AU - Moormann, Ann M.

AU - Vulule, John M.

AU - Narum, David L.

AU - Lanar, David E.

AU - Kazura, James W.

AU - John, Chandy

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