Low prevalence of Plasmodium falciparum infection among asymptomatic individuals in a highland area of Kenya

Chandy John, Marilyn M. McHugh, Ann M. Moormann, Peter O. Sumba, Ayub V. Ofulla

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

In areas of highly seasonal Plasmodium falciparum transmission, the presence of a large reservoir of persistently infected but asymptomatic individuals in the dry season leads to predictable increases in the incidence of clinical malaria in the rainy season. Highland areas, by contrast, are prone to unpredictable epidemics of malaria. To determine the importance of persistent asymptomatic infection in highland areas, we assessed asymptomatic individuals in the highland area of Kipsamoite, Kenya for the presence of P. falciparum blood-stage infection by microscopy and PCR. Five sample collections were performed during rainy and dry seasons over a 31-month period. The final collection was obtained at the start of a rainy season epidemic. Asymptomatic parasitemia was infrequent, ranging from 1.3 to 8.1% by microscopy and 5.9 to 14.5% by PCR testing. Microscopy had low sensitivity (22.2-54.8%) but excellent specificity (95.4-100%) in comparison to PCR testing. Frequency of asymptomatic parasitemia did not differ by age. Gametocyte prevalence was

Original languageEnglish (US)
Pages (from-to)780-786
Number of pages7
JournalTransactions of the Royal Society of Tropical Medicine and Hygiene
Volume99
Issue number10
DOIs
StatePublished - Oct 2005
Externally publishedYes

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Kenya
Plasmodium falciparum
Malaria
Microscopy
Parasitemia
Polymerase Chain Reaction
Asymptomatic Infections
Incidence
Infection

Keywords

  • Asymptomatic
  • Kenya
  • Malaria
  • Parasitemia
  • PCR
  • Plasmodium falciparum

ASJC Scopus subject areas

  • Parasitology
  • Medicine(all)

Cite this

Low prevalence of Plasmodium falciparum infection among asymptomatic individuals in a highland area of Kenya. / John, Chandy; McHugh, Marilyn M.; Moormann, Ann M.; Sumba, Peter O.; Ofulla, Ayub V.

In: Transactions of the Royal Society of Tropical Medicine and Hygiene, Vol. 99, No. 10, 10.2005, p. 780-786.

Research output: Contribution to journalArticle

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