Lower serum adiponectin levels in African-American boys

Mikako Degawa-Yamauchi, Jason R. Dilts, Jason E. Bovenkerk, Chandan Saha, J. Howard Pratt, Robert V. Considine

Research output: Contribution to journalArticle

48 Scopus citations


Objective: To examine adiponectin, an adipocyte-secreted hormone with anti-inflammatory and insulin-sensitizing effects, in relation to race or gender in younger subjects. Research Methods and Procedures: The relationship of adiponectin, quantitated by radioimmunoassay, to anthropometric and metabolic factors (fasting insulin, glucose, and leptin) and reproductive hormones was examined in 46 healthy African Americans (25 girls/21 boys) and 40 whites (20 girls/20 boys) ranging in age from 12 to 21 years. Results: There was no statistical difference in BMI or in BMI percentile among the four groups. Sums of skinfolds, but not skinfold percentile, were significantly lower in boys than girls (p = 0.001 and p = 0.896, respectively), whereas there was no difference between racial groups. Leptin was significantly greater in girls (p = 0.0002). There was no difference in fasting serum glucose, insulin, or homeostasis model assessment score among any of the groups. There was a significant negative univariate relationship between serum adiponectin and both BMI and BMI percentile for the entire group (p = 0.006 and p = 0.005). In a multivariate model, BMI percentile (p = 0.005) and the interaction between race and gender (p = 0.026) were significant predictors of serum adiponectin. In this model, African-American boys had the lowest serum adiponectin level, 37% less than white boys, who had the highest adiponectin levels. Discussion: Serum adiponectin levels are reduced in young obese subjects (African Americans and whites) and are lower in African-American boys than white boys. A lower adiponectin level in African-American boys may predispose this group to a greater risk of diabetes and cardiovascular disease.

Original languageEnglish (US)
Pages (from-to)1384-1390
Number of pages7
JournalObesity Research
Issue number11
StatePublished - Jan 1 2003


  • Adiponectin
  • African Americans
  • Insulin sensitivity

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Public Health, Environmental and Occupational Health
  • Endocrinology
  • Food Science
  • Endocrinology, Diabetes and Metabolism

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    Degawa-Yamauchi, M., Dilts, J. R., Bovenkerk, J. E., Saha, C., Pratt, J. H., & Considine, R. V. (2003). Lower serum adiponectin levels in African-American boys. Obesity Research, 11(11), 1384-1390. https://doi.org/10.1038/oby.2003.187