Lung cancer radiation therapy

Monte Carlo investigation of "under dose" by high energy photons

Paul M. DesRosiers, Vadim P. Moskvin, Colleen DesRosiers, Robert D. Timmerman, Marcus E. Randall, Lech S. Papiez

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Loss of electronic equilibrium in lung tissue causes a build-up region in the tumor. Increasing the photon energy increases the depth at which electronic equilibrium is reestablished within the lung tumor. This study uses the Monte Carlo code PENELOPE for simulations of radiation treatment of tumor surrounded by lung. Six MV photons were compared to 15 MV photons using four beam arrangements in both homogeneous and heterogeneous media. The experimental results demonstrate that for every beam arrangement in heterogeneous media 15 MV photons delivered 5% to 10% lower dose to the tumor periphery than 6 MV photons. The simulations also show that in axial coplanar treatment plans, the loss of electronic equilibrium was greatest in the coronal plane. In conclusion there is a tumor sparing effect at the tumor-lung interface that is a function of beam energy. As an alternative to increasing beam energy, the addition of multiple beam angles with lower energy photons improved target coverage. If higher energy beams are required for patients with large separation, then adding multiple beam angles does offer some improved target coverage. The non-coplanar technique with the lower energy photons covered the tumor with a greatest isodose at the tumor periphery without tangential sparing in the coronal plane.

Original languageEnglish
Pages (from-to)289-294
Number of pages6
JournalTechnology in Cancer Research and Treatment
Volume3
Issue number3
StatePublished - Jun 2004

Fingerprint

Photons
Lung Neoplasms
Radiotherapy
Neoplasms
Lung
Radiation
Therapeutics

Keywords

  • Dosimetry
  • Lung
  • Monte Carlo
  • Radiation

ASJC Scopus subject areas

  • Cancer Research
  • Radiology Nuclear Medicine and imaging

Cite this

DesRosiers, P. M., Moskvin, V. P., DesRosiers, C., Timmerman, R. D., Randall, M. E., & Papiez, L. S. (2004). Lung cancer radiation therapy: Monte Carlo investigation of "under dose" by high energy photons. Technology in Cancer Research and Treatment, 3(3), 289-294.

Lung cancer radiation therapy : Monte Carlo investigation of "under dose" by high energy photons. / DesRosiers, Paul M.; Moskvin, Vadim P.; DesRosiers, Colleen; Timmerman, Robert D.; Randall, Marcus E.; Papiez, Lech S.

In: Technology in Cancer Research and Treatment, Vol. 3, No. 3, 06.2004, p. 289-294.

Research output: Contribution to journalArticle

DesRosiers, PM, Moskvin, VP, DesRosiers, C, Timmerman, RD, Randall, ME & Papiez, LS 2004, 'Lung cancer radiation therapy: Monte Carlo investigation of "under dose" by high energy photons', Technology in Cancer Research and Treatment, vol. 3, no. 3, pp. 289-294.
DesRosiers, Paul M. ; Moskvin, Vadim P. ; DesRosiers, Colleen ; Timmerman, Robert D. ; Randall, Marcus E. ; Papiez, Lech S. / Lung cancer radiation therapy : Monte Carlo investigation of "under dose" by high energy photons. In: Technology in Cancer Research and Treatment. 2004 ; Vol. 3, No. 3. pp. 289-294.
@article{66fafb3aabff42739816e01c9f2f3416,
title = "Lung cancer radiation therapy: Monte Carlo investigation of {"}under dose{"} by high energy photons",
abstract = "Loss of electronic equilibrium in lung tissue causes a build-up region in the tumor. Increasing the photon energy increases the depth at which electronic equilibrium is reestablished within the lung tumor. This study uses the Monte Carlo code PENELOPE for simulations of radiation treatment of tumor surrounded by lung. Six MV photons were compared to 15 MV photons using four beam arrangements in both homogeneous and heterogeneous media. The experimental results demonstrate that for every beam arrangement in heterogeneous media 15 MV photons delivered 5{\%} to 10{\%} lower dose to the tumor periphery than 6 MV photons. The simulations also show that in axial coplanar treatment plans, the loss of electronic equilibrium was greatest in the coronal plane. In conclusion there is a tumor sparing effect at the tumor-lung interface that is a function of beam energy. As an alternative to increasing beam energy, the addition of multiple beam angles with lower energy photons improved target coverage. If higher energy beams are required for patients with large separation, then adding multiple beam angles does offer some improved target coverage. The non-coplanar technique with the lower energy photons covered the tumor with a greatest isodose at the tumor periphery without tangential sparing in the coronal plane.",
keywords = "Dosimetry, Lung, Monte Carlo, Radiation",
author = "DesRosiers, {Paul M.} and Moskvin, {Vadim P.} and Colleen DesRosiers and Timmerman, {Robert D.} and Randall, {Marcus E.} and Papiez, {Lech S.}",
year = "2004",
month = "6",
language = "English",
volume = "3",
pages = "289--294",
journal = "Technology in Cancer Research and Treatment",
issn = "1533-0346",
publisher = "Adenine Press",
number = "3",

}

TY - JOUR

T1 - Lung cancer radiation therapy

T2 - Monte Carlo investigation of "under dose" by high energy photons

AU - DesRosiers, Paul M.

AU - Moskvin, Vadim P.

AU - DesRosiers, Colleen

AU - Timmerman, Robert D.

AU - Randall, Marcus E.

AU - Papiez, Lech S.

PY - 2004/6

Y1 - 2004/6

N2 - Loss of electronic equilibrium in lung tissue causes a build-up region in the tumor. Increasing the photon energy increases the depth at which electronic equilibrium is reestablished within the lung tumor. This study uses the Monte Carlo code PENELOPE for simulations of radiation treatment of tumor surrounded by lung. Six MV photons were compared to 15 MV photons using four beam arrangements in both homogeneous and heterogeneous media. The experimental results demonstrate that for every beam arrangement in heterogeneous media 15 MV photons delivered 5% to 10% lower dose to the tumor periphery than 6 MV photons. The simulations also show that in axial coplanar treatment plans, the loss of electronic equilibrium was greatest in the coronal plane. In conclusion there is a tumor sparing effect at the tumor-lung interface that is a function of beam energy. As an alternative to increasing beam energy, the addition of multiple beam angles with lower energy photons improved target coverage. If higher energy beams are required for patients with large separation, then adding multiple beam angles does offer some improved target coverage. The non-coplanar technique with the lower energy photons covered the tumor with a greatest isodose at the tumor periphery without tangential sparing in the coronal plane.

AB - Loss of electronic equilibrium in lung tissue causes a build-up region in the tumor. Increasing the photon energy increases the depth at which electronic equilibrium is reestablished within the lung tumor. This study uses the Monte Carlo code PENELOPE for simulations of radiation treatment of tumor surrounded by lung. Six MV photons were compared to 15 MV photons using four beam arrangements in both homogeneous and heterogeneous media. The experimental results demonstrate that for every beam arrangement in heterogeneous media 15 MV photons delivered 5% to 10% lower dose to the tumor periphery than 6 MV photons. The simulations also show that in axial coplanar treatment plans, the loss of electronic equilibrium was greatest in the coronal plane. In conclusion there is a tumor sparing effect at the tumor-lung interface that is a function of beam energy. As an alternative to increasing beam energy, the addition of multiple beam angles with lower energy photons improved target coverage. If higher energy beams are required for patients with large separation, then adding multiple beam angles does offer some improved target coverage. The non-coplanar technique with the lower energy photons covered the tumor with a greatest isodose at the tumor periphery without tangential sparing in the coronal plane.

KW - Dosimetry

KW - Lung

KW - Monte Carlo

KW - Radiation

UR - http://www.scopus.com/inward/record.url?scp=2942655414&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=2942655414&partnerID=8YFLogxK

M3 - Article

VL - 3

SP - 289

EP - 294

JO - Technology in Cancer Research and Treatment

JF - Technology in Cancer Research and Treatment

SN - 1533-0346

IS - 3

ER -