Lung carcinoma with metastasis to testicular seminoma

J. Y. Ro, A. A. Sahin, A. G. Ayala, N. G. Ordonez, David Grignon, S. M. Popok

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Tumor-to-tumor metastases are uncommon. The most frequent donor tumors are the lung, whereas renal cell carcinoma is by far the most common recipient. In this report the authors describe a lung tumor that metastasized to a testicular seminoma. This is the first reported case of tumor-to-tumor metastases in which seminoma of the testis is the recipient. The authors performed mucin and immunohistochemical studies on this case and on ten cases of nonseminomatous germ cell tumors containing embryonal carcinoma and endodermal sinus tumor for comparison. Mucin positivity as well as immunoreactivity for epithelial membrane and carcinoembryonic antigens were confined to metastatic adenocarcinoma in this case, whereas Ki-1 and alpha-fetoprotein immunostaining were restricted to the ten control cases of germ cell tumors. Although the majority of second malignant components found in a seminoma are other nonseminomatous germ cell components, the rare possibility exists that a second malignant component is a metastasis from elsewhere in the body.

Original languageEnglish (US)
Pages (from-to)347-353
Number of pages7
JournalCancer
Volume66
Issue number2
DOIs
StatePublished - 1990
Externally publishedYes

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Seminoma
Neoplasm Metastasis
Carcinoma
Lung
Neoplasms
Mucins
Embryonal Carcinoma
Endodermal Sinus Tumor
Mucin-1
Germ Cell and Embryonal Neoplasms
Carcinoembryonic Antigen
alpha-Fetoproteins
Cellular Structures
Renal Cell Carcinoma
Germ Cells
Testis
Adenocarcinoma

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Lung carcinoma with metastasis to testicular seminoma. / Ro, J. Y.; Sahin, A. A.; Ayala, A. G.; Ordonez, N. G.; Grignon, David; Popok, S. M.

In: Cancer, Vol. 66, No. 2, 1990, p. 347-353.

Research output: Contribution to journalArticle

Ro, J. Y. ; Sahin, A. A. ; Ayala, A. G. ; Ordonez, N. G. ; Grignon, David ; Popok, S. M. / Lung carcinoma with metastasis to testicular seminoma. In: Cancer. 1990 ; Vol. 66, No. 2. pp. 347-353.
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