Lung function before and after pediatric allogeneic hematopoietic stem cell transplantation: A predictive role for DLCOa/VA

Troy C. Quigg, Young Jee Kim, W. Scott Goebel, Paul R. Haut

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

BACKGROUND:: Pre-allogeneic hematopoietic stem cell transplantation (aHSCT) and post-aHSCT lung function of 41 eligible patients at Riley Hospital for Children were assessed to identify risk factors for post-aHSCT morbidity and mortality. OBSERVATIONS:: One year post-aHSCT pulmonary function tests were significantly lower compared with baseline. These findings recovered at 2 years post-aHSCT. Refractory disease before aHSCT correlated with lower pulmonary function tests after aHSCT. Graft-versus-host disease was significantly associated with higher post-aHSCT residual volume. Importantly, low pre-aHSCT carbon monoxide diffusing capacity adjusted for hemoglobin and alveolar volume was predictive of death. CONCLUSIONS:: Among survivors, lung function improves over time after pediatric aHSCT. Measurement of carbon monoxide diffusing capacity adjusted for hemoglobin and alveolar volume before pediatric aHSCT should be further investigated as a predictor of pulmonary dysfunction and mortality.

Original languageEnglish (US)
Pages (from-to)304-309
Number of pages6
JournalJournal of Pediatric Hematology/Oncology
Volume34
Issue number4
DOIs
StatePublished - May 1 2012

Keywords

  • Allogeneic hematopoietic stem cell transplantation
  • DLCOa/VA
  • Graft-versus-host disease
  • Mortality
  • Pulmonary function tests

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Oncology
  • Hematology

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