Lung function from infancy to preschool in a cohort of children with cystic fibrosis

Lyndia C. Brumback, Stephanie Davis, Gwendolyn S. Kerby, Margaret Kloster, Robin Johnson, Robert Castile, Peter W. Hiatt, Meeghan Hart, Margaret Rosenfeld

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

This study aimed to describe lung function in a cohort of children with cystic fibrosis (CF) who underwent infant pulmonary function tests (IPFTs) and preschool spirometry. Children performed up to four IPFTs (raised volume rapid thoracic compression technique) over 1 yr and five preschool spirometry tests over up to 2 yrs during participation in prospective, multicentre studies of infant and preschool lung function. All lung function data were reviewed centrally for measurement acceptability. 45 children had 252 acceptable measurements (137 IPFTs and 115 preschool spirometries) at ages 0.3-6.5 yrs. The median number of measurements per participant was 6 (range 3-9). Recent Pseudomonas aeruginosa infection was associated with 5.1% (95% CI 0.01-9.9%) lower forced expiratory volume in 0.5 s (FEV0.5) and 16.4% (95% CI 7.0-24.9%) lower forced expiratory flow at 25-25% of forced vital capacity (FEF25-75%), after adjustment for length, test type and centre. Recent cough was associated with 5.7% (95% CI 1.1-10.1%) lower FEV0.5 and 10.1% (95% CI 0.6-18.7%) lower FEF25-75%. Even after accounting for infection status, cough, sex, length, test type and centre, there was significant inter-individual variability in lung function (p0.5, FEF25-75% and forced vital capacity). Recent P. aeruginosa infection and cough are associated with lower lung function in children with CF. Significant inter-individual variability in lung function remains to be explained. copyright

Original languageEnglish (US)
Pages (from-to)60-66
Number of pages7
JournalEuropean Respiratory Journal
Volume41
Issue number1
DOIs
StatePublished - Jan 1 2013
Externally publishedYes

Fingerprint

Cystic Fibrosis
Lung
Spirometry
Respiratory Function Tests
Cough
Pseudomonas Infections
Vital Capacity
Forced Expiratory Volume
Pseudomonas aeruginosa
Multicenter Studies
Thorax
Prospective Studies
Infection

Keywords

  • Cough
  • Pseudomonas aeruginosa
  • Raised volume rapid thoracic compression technique
  • Spirometry

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Brumback, L. C., Davis, S., Kerby, G. S., Kloster, M., Johnson, R., Castile, R., ... Rosenfeld, M. (2013). Lung function from infancy to preschool in a cohort of children with cystic fibrosis. European Respiratory Journal, 41(1), 60-66. https://doi.org/10.1183/09031936.00021612

Lung function from infancy to preschool in a cohort of children with cystic fibrosis. / Brumback, Lyndia C.; Davis, Stephanie; Kerby, Gwendolyn S.; Kloster, Margaret; Johnson, Robin; Castile, Robert; Hiatt, Peter W.; Hart, Meeghan; Rosenfeld, Margaret.

In: European Respiratory Journal, Vol. 41, No. 1, 01.01.2013, p. 60-66.

Research output: Contribution to journalArticle

Brumback, LC, Davis, S, Kerby, GS, Kloster, M, Johnson, R, Castile, R, Hiatt, PW, Hart, M & Rosenfeld, M 2013, 'Lung function from infancy to preschool in a cohort of children with cystic fibrosis', European Respiratory Journal, vol. 41, no. 1, pp. 60-66. https://doi.org/10.1183/09031936.00021612
Brumback, Lyndia C. ; Davis, Stephanie ; Kerby, Gwendolyn S. ; Kloster, Margaret ; Johnson, Robin ; Castile, Robert ; Hiatt, Peter W. ; Hart, Meeghan ; Rosenfeld, Margaret. / Lung function from infancy to preschool in a cohort of children with cystic fibrosis. In: European Respiratory Journal. 2013 ; Vol. 41, No. 1. pp. 60-66.
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