Lung function from infancy to preschool in a cohort of children with cystic fibrosis

Lyndia C. Brumback, Stephanie D. Davis, Gwendolyn S. Kerby, Margaret Kloster, Robin Johnson, Robert Castile, Peter W. Hiatt, Meeghan Hart, Margaret Rosenfeld

Research output: Contribution to journalArticle

14 Scopus citations


This study aimed to describe lung function in a cohort of children with cystic fibrosis (CF) who underwent infant pulmonary function tests (IPFTs) and preschool spirometry. Children performed up to four IPFTs (raised volume rapid thoracic compression technique) over 1 yr and five preschool spirometry tests over up to 2 yrs during participation in prospective, multicentre studies of infant and preschool lung function. All lung function data were reviewed centrally for measurement acceptability. 45 children had 252 acceptable measurements (137 IPFTs and 115 preschool spirometries) at ages 0.3-6.5 yrs. The median number of measurements per participant was 6 (range 3-9). Recent Pseudomonas aeruginosa infection was associated with 5.1% (95% CI 0.01-9.9%) lower forced expiratory volume in 0.5 s (FEV0.5) and 16.4% (95% CI 7.0-24.9%) lower forced expiratory flow at 25-25% of forced vital capacity (FEF25-75%), after adjustment for length, test type and centre. Recent cough was associated with 5.7% (95% CI 1.1-10.1%) lower FEV0.5 and 10.1% (95% CI 0.6-18.7%) lower FEF25-75%. Even after accounting for infection status, cough, sex, length, test type and centre, there was significant inter-individual variability in lung function (p<0.01 for each of FEV0.5, FEF25-75% and forced vital capacity). Recent P. aeruginosa infection and cough are associated with lower lung function in children with CF. Significant inter-individual variability in lung function remains to be explained. copyright

Original languageEnglish (US)
Pages (from-to)60-66
Number of pages7
JournalEuropean Respiratory Journal
Issue number1
StatePublished - Jan 1 2013
Externally publishedYes


  • Cough
  • Pseudomonas aeruginosa
  • Raised volume rapid thoracic compression technique
  • Spirometry

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Fingerprint Dive into the research topics of 'Lung function from infancy to preschool in a cohort of children with cystic fibrosis'. Together they form a unique fingerprint.

  • Cite this

    Brumback, L. C., Davis, S. D., Kerby, G. S., Kloster, M., Johnson, R., Castile, R., Hiatt, P. W., Hart, M., & Rosenfeld, M. (2013). Lung function from infancy to preschool in a cohort of children with cystic fibrosis. European Respiratory Journal, 41(1), 60-66.