Lung parenchymal development in premature infants without bronchopulmonary dysplasia

Santiago J. Assaf, Daniel V. Chang, Christina J. Tiller, Jeffrey A. Kisling, Jamie Case, Julie A. Mund, James E. Slaven, Zhangsheng Yu, Shawn K. Ahlfeld, Brenda Poindexter, Laura Haneline, David Ingram, Robert Tepper

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Rationale: While infants who are born extremely premature and develop bronchopulmonary dysplasia (BPD) have impaired alveolar development and decreased pulmonary diffusion (DLCO), it remains unclear whether infants born less premature and do not develop BPD, healthy premature (HP), have impaired parenchymal development. In addition, there is increasing evidence that pro-angiogenic cells are important for vascular development; however, there is little information on the relationship of pro-angiogenic cells to lung growth and development in infants. Objective: and Methods Determine among healthy premature (HP) and fullterm (FT) infants, whether DLCO and alveolar volume (VA) are related to gestational age at birth (GA), respiratory support during the neonatal period (mechanical ventilation [MV], supplemental oxygen [O2], continuous positive airway pressure [CPAP]), and pro-angiogenic circulating hematopoietic stem/progenitor cells (CHSPCs). We measured DLCO, VA, and CHSPCs in infants between 3-33 months corrected-ages; HP (mean GA=31.7wks; N=48,) and FT (mean GA=39.3wks; N=88). Result: DLCO was significantly higher in HP than FT subjects, while there was no difference in VA, after adjusting for body length, gender, and race. DLCO and VA were not associated with GA, MV and O2; however, higher values were associated with higher CHSPCs, as well as treatment with CPAP. Conclusion: Our findings suggest that in the absence of extreme premature birth, as well as BPD, prematurity per se, does not impair lung parenchymal development.

Original languageEnglish
JournalPediatric Pulmonology
DOIs
StateAccepted/In press - 2014

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Bronchopulmonary Dysplasia
Hematopoietic Stem Cells
Premature Infants
Lung
Continuous Positive Airway Pressure
Artificial Respiration
Premature Birth
Growth and Development
Gestational Age
Blood Vessels
Parturition
Oxygen

Keywords

  • Circulating progenitor cells
  • Lung growth
  • Lung volume
  • Pulmonary diffusion

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pulmonary and Respiratory Medicine

Cite this

Lung parenchymal development in premature infants without bronchopulmonary dysplasia. / Assaf, Santiago J.; Chang, Daniel V.; Tiller, Christina J.; Kisling, Jeffrey A.; Case, Jamie; Mund, Julie A.; Slaven, James E.; Yu, Zhangsheng; Ahlfeld, Shawn K.; Poindexter, Brenda; Haneline, Laura; Ingram, David; Tepper, Robert.

In: Pediatric Pulmonology, 2014.

Research output: Contribution to journalArticle

Assaf, Santiago J. ; Chang, Daniel V. ; Tiller, Christina J. ; Kisling, Jeffrey A. ; Case, Jamie ; Mund, Julie A. ; Slaven, James E. ; Yu, Zhangsheng ; Ahlfeld, Shawn K. ; Poindexter, Brenda ; Haneline, Laura ; Ingram, David ; Tepper, Robert. / Lung parenchymal development in premature infants without bronchopulmonary dysplasia. In: Pediatric Pulmonology. 2014.
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AU - Chang, Daniel V.

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AU - Kisling, Jeffrey A.

AU - Case, Jamie

AU - Mund, Julie A.

AU - Slaven, James E.

AU - Yu, Zhangsheng

AU - Ahlfeld, Shawn K.

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AU - Haneline, Laura

AU - Ingram, David

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N2 - Rationale: While infants who are born extremely premature and develop bronchopulmonary dysplasia (BPD) have impaired alveolar development and decreased pulmonary diffusion (DLCO), it remains unclear whether infants born less premature and do not develop BPD, healthy premature (HP), have impaired parenchymal development. In addition, there is increasing evidence that pro-angiogenic cells are important for vascular development; however, there is little information on the relationship of pro-angiogenic cells to lung growth and development in infants. Objective: and Methods Determine among healthy premature (HP) and fullterm (FT) infants, whether DLCO and alveolar volume (VA) are related to gestational age at birth (GA), respiratory support during the neonatal period (mechanical ventilation [MV], supplemental oxygen [O2], continuous positive airway pressure [CPAP]), and pro-angiogenic circulating hematopoietic stem/progenitor cells (CHSPCs). We measured DLCO, VA, and CHSPCs in infants between 3-33 months corrected-ages; HP (mean GA=31.7wks; N=48,) and FT (mean GA=39.3wks; N=88). Result: DLCO was significantly higher in HP than FT subjects, while there was no difference in VA, after adjusting for body length, gender, and race. DLCO and VA were not associated with GA, MV and O2; however, higher values were associated with higher CHSPCs, as well as treatment with CPAP. Conclusion: Our findings suggest that in the absence of extreme premature birth, as well as BPD, prematurity per se, does not impair lung parenchymal development.

AB - Rationale: While infants who are born extremely premature and develop bronchopulmonary dysplasia (BPD) have impaired alveolar development and decreased pulmonary diffusion (DLCO), it remains unclear whether infants born less premature and do not develop BPD, healthy premature (HP), have impaired parenchymal development. In addition, there is increasing evidence that pro-angiogenic cells are important for vascular development; however, there is little information on the relationship of pro-angiogenic cells to lung growth and development in infants. Objective: and Methods Determine among healthy premature (HP) and fullterm (FT) infants, whether DLCO and alveolar volume (VA) are related to gestational age at birth (GA), respiratory support during the neonatal period (mechanical ventilation [MV], supplemental oxygen [O2], continuous positive airway pressure [CPAP]), and pro-angiogenic circulating hematopoietic stem/progenitor cells (CHSPCs). We measured DLCO, VA, and CHSPCs in infants between 3-33 months corrected-ages; HP (mean GA=31.7wks; N=48,) and FT (mean GA=39.3wks; N=88). Result: DLCO was significantly higher in HP than FT subjects, while there was no difference in VA, after adjusting for body length, gender, and race. DLCO and VA were not associated with GA, MV and O2; however, higher values were associated with higher CHSPCs, as well as treatment with CPAP. Conclusion: Our findings suggest that in the absence of extreme premature birth, as well as BPD, prematurity per se, does not impair lung parenchymal development.

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KW - Pulmonary diffusion

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