Lung transplantation: Opportunities for research and clinical advancement

David S. Wilkes, Thomas M. Egan, Herbert Y. Reynolds

Research output: Contribution to journalArticle

75 Scopus citations

Abstract

Lung transplantation is the only definitive therapy for many forms of end-stage lung diseases. However, the success of lung transplantation is limited by many factors: (1) Too few lungs available for transplantation due to limited donors or injury to the donor lung; (2) current methods of preservation of excised lungs do not allow extended periods of time between procurement and implantation; (3) acute graft failure is more common with lungs than other solid organs, thus contributing to poorer short-term survival after lung transplant compared with that for recipients of other organs; (4) lung transplant recipients are particularly vulnerable to pulmonary infections; and (5) chronic allograft dysfunction, manifest by bronchiolitis obliterans syndrome, is frequent and limits long-term survival. Scientific advances may provide significant improvements in the outcome of lung transplantation. The National Heart, Lung, and Blood Institute convened a working group of investigators on June 14-15, 2004, in Bethesda, Maryland, to identify opportunities for scientific advancement in lung transplantation, including basic and clinical research. This workshop provides a framework to identify critical issues related to clinical lung transplantation, and to delineate important areas for productive scientific investigation.

Original languageEnglish (US)
Pages (from-to)944-955
Number of pages12
JournalAmerican journal of respiratory and critical care medicine
Volume172
Issue number8
DOIs
StatePublished - Oct 15 2005

Keywords

  • Allograft dysfunction
  • Infection
  • Ischemia-reperfusion injury
  • Lung transplantation
  • Obliterative bronchiolitis
  • Rejection

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine

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