Lupus erythematosus-like disease due to hydrazine

Marcus M. Reidenberg, Pamela J. Durant, Robert Harris, Grace De Boccardo, Robert Lahita, Kurt H. Stenzel

Research output: Contribution to journalArticle

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Abstract

A case of systemic lupus erythematosus-like disease due to occupational exposure to hydrazine is described. The patient had four of the 1982 revised criteria for SLE (malar rash, photosensitivity, antinuclear antibody, and antibody to nDNA) and genetically is a slow acetylator with the HLA DR2,3 phenotype. Many of her healthy family members had antibodies to nuclear constituents. Lymphocytes from the patient and an identical twin sister, but not from three normal control subjects, showed inhibition of pokeweed mitogenstimulated IgG synthesis after five daily exposures of each subject to hydrazine. Chemicals such as hydrazine in the environment can induce cases of SLE-like disease in predisposed persons.

Original languageEnglish
Pages (from-to)365-370
Number of pages6
JournalThe American Journal of Medicine
Volume75
Issue number2
DOIs
StatePublished - 1983
Externally publishedYes

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hydrazine
Phytolacca americana
HLA-DR2 Antigen
Monozygotic Twins
Antibodies
Antinuclear Antibodies
Occupational Exposure
Exanthema
Systemic Lupus Erythematosus
Siblings
Immunoglobulin G
Lymphocytes
Phenotype

ASJC Scopus subject areas

  • Nursing(all)

Cite this

Reidenberg, M. M., Durant, P. J., Harris, R., De Boccardo, G., Lahita, R., & Stenzel, K. H. (1983). Lupus erythematosus-like disease due to hydrazine. The American Journal of Medicine, 75(2), 365-370. https://doi.org/10.1016/0002-9343(83)91219-6

Lupus erythematosus-like disease due to hydrazine. / Reidenberg, Marcus M.; Durant, Pamela J.; Harris, Robert; De Boccardo, Grace; Lahita, Robert; Stenzel, Kurt H.

In: The American Journal of Medicine, Vol. 75, No. 2, 1983, p. 365-370.

Research output: Contribution to journalArticle

Reidenberg, MM, Durant, PJ, Harris, R, De Boccardo, G, Lahita, R & Stenzel, KH 1983, 'Lupus erythematosus-like disease due to hydrazine', The American Journal of Medicine, vol. 75, no. 2, pp. 365-370. https://doi.org/10.1016/0002-9343(83)91219-6
Reidenberg, Marcus M. ; Durant, Pamela J. ; Harris, Robert ; De Boccardo, Grace ; Lahita, Robert ; Stenzel, Kurt H. / Lupus erythematosus-like disease due to hydrazine. In: The American Journal of Medicine. 1983 ; Vol. 75, No. 2. pp. 365-370.
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