Lymphatic vessel density in radical prostatectomy specimens

Liang Cheng, Elena Bishop, Honghong Zhou, Gregory T. MacLennan, Antonio Lopez-Beltran, Shaobo Zhang, Sunil Badve, Lee Ann Baldridge, Rodolfo Montironi

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Formation of new lymphatic channels, or lymphangiogenesis, has been associated with poor prognosis in a number of human cancers. Its prognostic significance in prostate cancer is uncertain. We analyzed 122 radical prostatectomy specimens. Immunohistochemistry for lymphatic vessels was performed using a mouse monoclonal antibody reactive with an O-linked sialoglycoprotein found on lymphatic endothelium (clone D2-40, Signet Laboratories, Dedham, Mass). The mean lymphatic vessel densities (LVDs) of the 3 prostate compartments were compared. Lymphatic vessel densities were correlated with other clinical and pathologic characteristics. Mean values for intratumoral, peritumoral, and normal prostate LVD were 3.0, 5.2, and 4.8 lymphatic vessels per 200× field, respectively. The intratumoral LVD was significantly lower than the peritumoral or normal LVD (P < .001), and the LVD of the latter 2 compartments was not significantly different (P = .29). The prostate LVD did not correlate with other clinical and pathologic parameters. In conclusion, LVD is reduced in the intratumoral compartment compared with the peritumoral and normal prostate compartments, whereas the latter 2 have similar LVD. In contrast to other malignancies, quantitation of lymphangiogenesis in prostatic adenocarcinoma does not appear to offer useful prognostic information.

Original languageEnglish
Pages (from-to)610-615
Number of pages6
JournalHuman Pathology
Volume39
Issue number4
DOIs
StatePublished - Apr 2008

Fingerprint

Lymphatic Vessels
Prostatectomy
Prostate
Lymphangiogenesis
Lymphatic Endothelium
Sialoglycoproteins
Neoplasms
Prostatic Neoplasms
Adenocarcinoma
Clone Cells
Immunohistochemistry
Monoclonal Antibodies

Keywords

  • Angiogenesis
  • Biomarkers
  • Lymphatic vessel density
  • Metastasis
  • Prostate

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Cheng, L., Bishop, E., Zhou, H., MacLennan, G. T., Lopez-Beltran, A., Zhang, S., ... Montironi, R. (2008). Lymphatic vessel density in radical prostatectomy specimens. Human Pathology, 39(4), 610-615. https://doi.org/10.1016/j.humpath.2007.09.006

Lymphatic vessel density in radical prostatectomy specimens. / Cheng, Liang; Bishop, Elena; Zhou, Honghong; MacLennan, Gregory T.; Lopez-Beltran, Antonio; Zhang, Shaobo; Badve, Sunil; Baldridge, Lee Ann; Montironi, Rodolfo.

In: Human Pathology, Vol. 39, No. 4, 04.2008, p. 610-615.

Research output: Contribution to journalArticle

Cheng, L, Bishop, E, Zhou, H, MacLennan, GT, Lopez-Beltran, A, Zhang, S, Badve, S, Baldridge, LA & Montironi, R 2008, 'Lymphatic vessel density in radical prostatectomy specimens', Human Pathology, vol. 39, no. 4, pp. 610-615. https://doi.org/10.1016/j.humpath.2007.09.006
Cheng, Liang ; Bishop, Elena ; Zhou, Honghong ; MacLennan, Gregory T. ; Lopez-Beltran, Antonio ; Zhang, Shaobo ; Badve, Sunil ; Baldridge, Lee Ann ; Montironi, Rodolfo. / Lymphatic vessel density in radical prostatectomy specimens. In: Human Pathology. 2008 ; Vol. 39, No. 4. pp. 610-615.
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