Lymphocyte subset differences in patients with chronic fatigue syndrome, multiple sclerosis and major depression

M. J. Robertson, R. S. Schacterle, G. A. Mackin, S. N. Wilson, K. L. Bloomingdale, J. Ritz, A. L. Komaroff

Research output: Contribution to journalArticle

67 Scopus citations


Chronic fatigue syndrome (CFS) is a heterogeneous disorder of unknown aetiology characterized by debilitating fatigue, along with other symptoms, for at least 6 months. Many studies demonstrate probable involvement of the central and autonomic nervous system, as well as a state of generalized immune activation and selective immune dysfunction in patients with CFS. The aim of this study was to compare the lymphocyte subsets of patients with chronic fatigue syndrome to those of patients with major depression and multiple sclerosis as well as those of healthy control subjects. No differences were found in total numbers of T cells, B cells or natural killer (NK) cells. However, differences were found in T, B and NK cell subsets. Patients with major depression had significantly fewer resting T (CD3+/CD25-) cells than the other groups. Patients with major depression also had significantly more CD20+/CD5+ B cells, a subset associated with the production of autoantibodies. Compared to patients with multiple sclerosis, patients with CFS had greater numbers of CD16+/CD3 - NK cells. Further study will be required to determine whether these alterations in lymphocyte subsets are directly involved in the pathophysiology of these disorders, or are secondary effects of the causal agent(s).

Original languageEnglish (US)
Pages (from-to)326-332
Number of pages7
JournalClinical and Experimental Immunology
Issue number2
StatePublished - Aug 2005


  • B cell
  • Chronic fatigue syndrome
  • Depression
  • Multiple sclerosis
  • NK cell
  • T cell

ASJC Scopus subject areas

  • Immunology

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